Anticancer Activity of Medicinal Plant Berberis balochistanica and Sophora alopecuroides: A Brief Review
DOI:
https://doi.org/10.31580/pjmls.v7isp2.3163Keywords:
Anticancer activity, Berberis balochistanica, Medicinal plants, Sophora alopecuroides, Traditional medicineAbstract
Cancer is characterized by the spread of abnormal cells and unchecked growth. Cancer is the 2nd most significant leading cause of death. The human population worldwide is severely affected by cancer. This life-threatening disease is constantly being sought out for new therapies to treat and prevent. The attention of scientists is being drawn to compounds that come from nature, as they are considered less toxic than other cancer treatments. Plants have been used for medicinal purposes by many ancient civilisations, and research has shown that plant-derived compounds can be helpful in treating cancer. The herbal medicine system throughout Pakistan utilizes numerous plants that are well known for their remedial potential. Balochistan is known for its abundance of medicinal plants. These therapeutic plants are used by native people to treat various disease. Berberis have been reported as a medicinal plant in folklore and has been used in traditional medicine in Asia. Berberis balochistanica is a remedial herb. Isoquinoline alkaloids and berberine are present in the genus Berberis. It has been reported that they have anticancer activities and effects on the cardiovascular and immune system. Sophora alopecuroides main key bioactive compounds are Quinolizidine alkaloids, which include Sophoridine, Oxysophocarpine, Sophocaepine, Oxymatrine and Matrine. S. alopecuroides alkaloids have significant biological activities and are used in medical trials, which have a pharmacological action of tumor suppression and anti-cancer. This review aims to summarize the current knowledge about the anticancer potential of Berberis balochistanica and Sophora alopecuroides and highlight their therapeutic prospects and naturally derived compounds from medicinal plants and their constituents that could potentially be used as targets for anticancer treatments.
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