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Abstract
Uric acid is a natural substance produced endogenously as a purine metabolite and excreted by the kidney. Excessive production or less excretion of uric acid can lead to hyperuricemia, which is associated with number of risk factors, such as gout and metabolic syndromes. The prevalence of cardiovascular disease, diabetes mellitus, gout, kidney and obesity is rapidly increasing. However, the underlying causes of these conditions, including high SUA has been ignored The purpose of the present study was to determine the gender- based relationship between serum uric acid levels and its risk factors in hyperuricemic patients of Quetta city. Since no work has been done in Balochistan related to this topic. so the present research is an attempt to fill this gap. The study was carried out on hyper urecemic patients who received routine medical examinations at Sandeman Provincial Hospital, Quetta. Blood samples were obtained from 100 hyperuricemia patients and analyzed for the identification of serum uric acid levels in laboratory. Clinical, demographical, lifestyle and dietary data of participants were also recorded through a self-designed questionnaire. All the data were evaluated using SPSS version 24. The data was analyzed as the mean ± SD, χ2-test, t test and percentages (%). The mean of SUA in both genders was 8.2920 and 7.410 mg /dl in males and females, respectively with a significant association p=0.005<.05. Most of the hyperuricemia patients belonged to age group 45-54. The average age of male and female patients was 48.62 and 43.54 respectively (p=0.016). The study found a non-significant relationship of BMI value in male and female hyperuricemia patients, whereas a non-significant association between the incidence of hyperuricemia and ethnicities was found (p value 0.19 > .05). Patient characteristics including gender, hypertension, renal problems, dairy products intake and sea food intake showed statistical significant association with SUA levels between genders. A non-significant association was found between diabetes, heart disease, kidney disorder and family history with hyperuricemia
This study is a quantitative research and it is significant in many ways. It will highlight the level of serum uric acid in the population of Quetta city. It will also embark upon the prevalence of hyperuricemia in different ethnicities of Quetta City and it is an attempt to identify the risk factors associated with hyperuricemia in male and female adults. ulphate of potash (SOP) levels; and the sweet pepper fertilized with T4 = SOP = 60 g/kg resulted in highest.
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