Ageing Affects the Myo-Nulcear Domain in the Slow and Fast Muscle Fiber Depicting the Myofibers-Specific Dissimilarities with the Age
DOI:
https://doi.org/10.31580/pjmls.v4i3.1163Keywords:
Myonuclear domain, Skeletal muscle, Vastus lateralis, AgeingAbstract
Myonuclei, the satellite cells that are present beneath sarcolemma, play an essential part in the maintenance and growth of myofibres. The myonuclear domain controls the cytoplasm of satellite cells. Scientists have established that atrophic variation exists in both skeletal muscles fibres with increasing age. It is critical to determine the relationship between ageing and the myonuclear domain in human skeletal muscles, and in the current study we analysed the impact of age on fibre specific relationships of the myonuclear domain. The myofibres was evaluated in Vastus lateralis muscles of the young adults (n = 9) and older adults (n = 8). We found no sizeable variations in myofibres composition of young and old subjects. Fibre cross-sectional area of type I fibre was similar, but substantial atrophic changes (12%) were observed in type II fibres in older adults compared to young ones. The older adults acquired a lot more myonuclei, resulting in a considerably reduced size of the myonuclear domain of type II fibres. We surmised that myofibres-specific dissimilarities occur due to ageing effects on a myonuclear domain, probably due to the diminishing capability of the myonuclear content of fast muscle fibres. This phenomenon can be helpful in devising the combating strategies to prevent it.
References
Wang J, Khodabukus A, Rao L, Vandusen K, Abutaleb N, Bursac N. Engineered skeletal
muscles for disease modeling and drug discovery. Biomaterials. 2019;221:119416.
Goldspink D. The influence of contractile activity and the nerve supply on muscle size and
protein turnover. Plasticity of muscle: De Gruyter; 2019. p. 525-40.
Eisenberg B, Jacobs-El J. Are satellite cells essential for isomyosin switching? The
dynamic state of muscle fibers: De Gruyter; 2019. p. 681-92.
Cramer AA, Prasad V, Eftestøl E, Song T, Hansson K-A, Dugdale HF, et al. Nuclear
numbers in syncytial muscle fibers promote size but limit the development of larger
myonuclear domains. Nature communications. 2020;11(1):1-14.
Snijders T, Holwerda AM, van Loon LJ, Verdijk LB. Myonuclear content and domain size in small versus larger muscle fibres in response to 12 weeks of resistance exercise training in older adults. Acta Physiologica. 2021;231(4):e13599.
Moro T, Brightwell CR, Volpi E, Rasmussen BB, Fry CS. Resistance exercise training promotes fiber type-specific myonuclear adaptations in older adults. Journal of Applied Physiology. 2020;128(4):795-804.
Machek SB, Lorenz KA, Kern M, Galpin AJ, Bagley JR. Skeletal muscle fiber type and morphology in a middle-aged elite male powerlifter using anabolic steroids. Journal of Science in Sport and Exercise. 2019:1-8.
Blocquiaux S, Gorski T, Van Roie E, Ramaekers M, Van Thienen R, Nielens H, et al. The effect of resistance training, detraining and retraining on muscle strength and power, myofibre size, satellite cells and myonuclei in older men. Experimental gerontology. 2020;133:110860.
Murach KA, Dungan CM, Dupont-Versteegden EE, McCarthy JJ, Peterson CA. “Muscle memory” not mediated by myonuclear number? Secondary analysis of human detraining data. Journal of Applied Physiology. 2019;127(6):1814-6.
McKendry J, Joanisse S, Baig S, Liu B, Parise G, Greig CA, et al. Superior aerobic capacity and indices of skeletal muscle morphology in chronically trained master endurance athletes compared with untrained older adults. The Journals of Gerontology: Series A. 2020;75(6):1079-88.
Snijders T, Nederveen JP, Bell KE, Lau SW, Mazara N, Kumbhare DA, et al. Prolonged exercise training improves the acute type II muscle fibre satellite cell response in healthy older men. The Journal of physiology. 2019;597(1):105-19.
Qamar MM, Qamar MF. Strength training restores morphological changes occur during aging. Medical Channel. 2014;20(1).
Distefano G, Goodpaster BH. Effects of Exercise and Aging on Skeletal Muscle. Cold Spring Harbor perspectives in medicine. 2018;8(3).
Beasley JM, Shikany JM, Thomson CA. The role of dietary protein intake in the prevention of sarcopenia of aging. Nutrition in clinical practice. 2013;28(6):684-90.
Cebrià i Iranzo MA, Arnal-Gómez A, Tortosa-Chuliá MA, Balasch-Bernat M, Forcano S, Sentandreu-Mañó T, et al. Functional and clinical characteristics for predicting sarcopenia in institutionalised older adults: Identifying tools for clinical screening. International Journal of Environmental Research and Public Health. 2020;17(12):4483.
Bruyère O, Beaudart C, Ethgen O, Reginster J-Y, Locquet M. The health economics burden of sarcopenia: a systematic review. Maturitas. 2019;119:61-9.
Yoshihara T, Naito H. Protective effects of acute exercise preconditioning on disuse-induced muscular atrophy in aged muscle: a narrative literature review. The Journal of Physiological Sciences. 2020;70(1):1-5.
Sartori R, Romanello V, Sandri M. Mechanisms of muscle atrophy and hypertrophy: Implications in health and disease. Nature Communications. 2021;12(1):1-12.
Ecarnot F, Rogoli D, Maggi S. Epidemiology of Sarcopenia. Sarcopenia: Springer; 2021. p. 1-16.
Bårdstu HB, Andersen V, Fimland MS, Aasdahl L, Raastad T, Cumming KT, et al. Effectiveness of a resistance training program on physical function, muscle strength, and body composition in community-dwelling older adults receiving home care: a cluster-randomized controlled trial. European review of aging and physical activity. 2020;17(1):1-11.
Verdijk LB, Snijders T, Beelen M, Savelberg HH, Meijer K, Kuipers H, et al. Characteristics of muscle fiber type are predictive of skeletal muscle mass and strength in elderly men. Journal of the American Geriatrics Society. 2010;58(11):2069-75.
