PHYSIOLOGICAL ASPECTS OF EFFECTIVE AND SAFE PROTON PUMP INHIBITOR THERAPY FOR ACID SUPPRESSION IN QUETTA

Abstract

ABSTRACT

Prescribing proton pump inhibitors for a long time is a rational practice nowadays. In some cases, patients with peptic ulcers have to take them for their whole life. Patients have to use PPIs, and there is evolving distress due to the strong antagonistic effects as a result of their continuous therapy. The first discovered proton pump inhibitor is omeprazole, and after some time of discovery of omeprazole, the French gastroenterologist Jean Paul Galmiche anticipated that the unprecedented clinical effectiveness of this medicine would have led (patients and physicians alike) to dependence, and indeed, this is the case. Once proton pump inhibitor PPI, used by a large number of patients for long-term, the proton pump inhibitors, often, may result in bone weakness and sometimes cardiac distress. Especially in mature women. Even though PPIs are ideal anti-secretory drugs and innovative longer-acting compounds that have developed  prolonged acid suppression, they remain, no doubt, prescribed in all age groups and give very effective results among all  available medications