Elucidation of Neurobehavioral Dynamics and Antioxidant properties Following Oral Administration of Fenugreek seeds in Rats

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Published: 2026-03-31
DOI: https://doi.org/10.31580/wj3yca76
Keywords:
Antioxidant, Depression, Fenugreek, Memory, Medicinal

Main Article Content

Irfan Sajid
Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan
Hafsah Khan
Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan
Shoaib Ahmed
Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan
Lubna Anis
Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan
Munawwar Abbas
Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan
Palwasha Abrar
Department of Biochemistry, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan
Syed Ikhlaq Hussain
Department of Zoology, Federal Urdu University of Arts, Science and Technology, Karachi, Pakistan

Abstract

Fenugreek seeds are small in size, yellowish brown and bitter in taste. It is used as an old medicinal plant as Ayurvedic and Chinese medicine. Present study is designed to evaluate neurobehavioral effects following fenugreek seeds administration in male albino rats. Twelve albino rats were categorized into control and test groups. Control was given normal saline while test was given 200 mg/kg fenugreek seeds aqueous solution in oral form for three weeks. Force swimming test used for depression-like symptoms and anxiety by using elevated plus maze test. While memory and learning functions were evaluated by using Morris water maze test. Antioxidant activities evaluated by measuring levels of malondialdehyde (MDA) and Catalase activity in brain.The effect 200 mg/kg for three weeks of fenugreek seeds significantly increase the memory and muscles strength accompanied by notable antioxidant effects. Whereas no significant results on depression-like symptoms and anxiety functions were found. It is concluded that study reveals about the significant effect of fenugreek seed administration on memory functions and on antioxidant enzyme activity.

Article Details

Issue

Vol. 9 No. 1 (2026): January-March 2026

Section

Research Article
Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

Elucidation of Neurobehavioral Dynamics and Antioxidant properties Following Oral Administration of Fenugreek seeds in Rats. (2026). Pak-Euro Journal of Medical and Life Sciences, 9(1), 201-208. https://doi.org/10.31580/wj3yca76

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