Serum Bilirubin Levels as a Diagnostic Indicator for Various Ailments in Patients with Hyperbilirubinemia
DOI:
https://doi.org/10.31580/g88y4185Keywords:
Biosynthesis, Bilirubin , Hyperbilirubinemia, Jaundice, TransportationAbstract
This study examines the prevalence and clinical significance of hyperbilirubinemia across various diseases, including jaundice, hepatitis, malaria, anemia, and other conditions. A total of 171 patients from District Headquarters (DHQ) Hospital Timargara and private clinical laboratories were analyzed for bilirubin levels. The patients were grouped as follows: 77 with newborn jaundice, 19 with hepatitis B, 17 with hepatitis C, 17 with malaria, 9 with anemia, and 26 with miscellaneous diseases.
The results showed that 96.15% of newborn jaundice cases had elevated bilirubin levels ranging from 6 to 18 mg/dL, which normalized within 1 to 4 weeks. Among hepatitis B and C patients, elevated bilirubin levels were observed in 80% and 73.7% of cases, respectively, with the highest bilirubin level recorded at 6.8 mg/dL in hepatitis B patients. All patients with malaria and anemia presented with hyperbilirubinemia, though specific levels varied. In the miscellaneous diseases group, 30% exhibited elevated bilirubin. Interestingly, a subgroup of 4 patients showed asymptomatic hyperbilirubinemia, characterized by elevated bilirubin without clinical symptoms.
Statistical analysis revealed no significant correlation between bilirubin levels and other liver function tests (ALT, ALP), indicating that hyperbilirubinemia in conditions such as malaria and anemia may not always follow typical liver enzyme patterns. These findings highlight the importance of a comprehensive diagnostic approach, incorporating additional tests like liver imaging and genetic screening, to improve diagnostic accuracy and deepen understanding of the underlying causes of hyperbilirubinemia.
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