Epidemiology and clinical Menifestation of Covid 19

Abstract

Abstract
The severe acute respiratory syndrome outbreak occurred in Wuhan city, Hubei Province, China in December 2019. World Health Organization and international committee on taxonomy of viruses termed the current name for the Covid-19 as Sever acute respiratory syndrome Corona virus (SARS -Cov-2). It is estimated that incubation period is 14 days and infected patient have usually fever and low respiratory tract symptoms. Clinical manifestation symptoms assortment from mild to severe and severe condition can lead to death. Diagnosis based on morphological identification of virus by electron Microscopy, nasopharyngeal or oropharyngeal swabs sample collection and real time – PCR and genome sequencing. Corona virus is an enveloped, positive sense, single stranded RNA virus belongs to family corona viridae. There are of the seven human corona virus types which cause respiratory disease. SARS – Cov – 2 is seventh corona virus and third known epidemic of corona virus after SARS -Cov-1 and MERS and all these three members of corona virus belong to the beta corona virus cluster. Receptor binding domain most mutable part of the corona virus genome which is present in spikes protein. Current studies revealed that transmission of COVID-19 in human to human occurred by respiratory droplets. There has been no proven effective current antiviral drug and vaccine available for COVID- 19. There for WHO and CDC recommend precautionary measurements to overcome the spread of Covid-19 include initial diagnosis ,proper reporting , isolation , basic personal hygiene like frequently hand washing ,use of surgical Mask , social distancing can effectively prevent the spread of Covid-19.