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The major contributing factor in the development of heart diseases is hyperlipidemia. Hyperlipidemia is one of those health issues originates from excessive consumption of unhealthy fats. The number of individuals with the problem of hyperlipidemia is increasing globally. But these numbers can be reduced with dietary modifications, lifestyle changes, and consumption of specific therapeutic foods. Different food commodities are known to have hypolipidemic potential. Flax seeds and chia seeds possess hypolipidemic properties due to the presence of large amounts of dietary fibre, unsaturated fatty acids and antioxidants. The present study was composed to examine the effect of different combinations of flax and chia seeds powder (50%+ 50%, 70%+30% and 30%+70% respectively) on serum lipid profile. An efficacy study was performed on rats, and hyperlipidemia was induced by giving a high-fat diet for a period of 15 days. The blood samples were collected after the period of induction and at the end of the study. The most observable effect was showed by the group who treated with 70% flax and 30% chia seed with normal diet. The reduction in TC 106.520.39→88.200.55 mg/dl, TGs by 164.180.56→140.720.26 mg/dl, LDL-C 59.090.44→51.810.96 mg/dl and an increase in HDL-C by 25.960.23→32.030.45 mg/dl was observed. The findings of the current study revealed that both flax and chia seeds are helpful in the maintenance of health by lowering lipid levels, which can be associated with the dietary fiber and fatty acid composition.References
1. Fatima T. Cardiovascular diseases are considered to be the leading cause of deaths all over the world and it is anticipated that the number of deaths due to CVDs may augment by the year 2020. Int J Pharm Res. 2017; 8:110-124.
2. Martinez-Hervas S, Ascaso JF. Hypercholesterolemia. Span Biomed Res Centre Diabetes Assoc Metab Disord. 2018; 44:1274-1283.
3. Nirosha K, Divya M, Vamsi S, Sadiq M. A review on hyperlipidemia. Int J Novel Trends Pharm Sci. 2014; 4:81-92.
4. Dhaliya SA, Surya AS, Dawn VT, Betty C, Arun K, Sunil C. A review of hyperlipidemia and medicinal plants. Int J Adv Pharm Sci. 2013; 2:219-237.
5. Kaur P, Waghmare R, Kumar V, Rasane P, Kaur S, Gat Y. Recent advances in utilization of flaxseed as potential source for value addition. OCL. 2018; 25:115-132.
6. Ullah R, Nadeem M, Khalique A, Imran M, Mehmood S, Javid A, Hussain J. Nutritional and therapeutic perspectives of Chia (Salvia hispanica L.): a review. J Food Sci Technol. 2016; 53:1750-1758.
7. Soltani KS, Jamal Uddin R, Tabibi H, Mohd Yusof BN, Atabak S, Loh SP, Rahmani L. Effects of flaxseed consumption on systemic inflammation and serum lipid profile in hemodialysis patients with lipid abnormalities. Hemodial Int. 2013;17:275-281.
8. Da Silva BP, Dias DM, de Castro Moreira ME, Toledo RCL, da Matta SLP, Della Lucia CM, Martino HSD, Pinheiro-Sant’Ana HM. Chia seed shows good protein quality, hypoglycemic effect and improves the lipid profile and liver and intestinal morphology of Wistar rats. Plant Foods Hum Nutr. 2016; 71:225-230.
9. Dodin S, Lemay A, Jacques H, Legare F, Forest JC, Masse B. The effects of flaxseed dietary supplement on lipid profile, bone mineral density, and symptoms in menopausal women: a randomized, double-blind, wheat germ placebo-controlled clinical trial. J Clin Endocrinol Metab. 2005; 90:1390-1397.
10. Montgomery DC. Design and analysis of experiments. 7th ed. Hoboken: John Wiley & Sons; 2008. p. 1-656.
11. Torkan M, Hassan Entezari M, Siavash M. Effect of flaxseed on blood lipid level in hyperlipidemic patients. Rev Recent Clin Trials. 2015; 10:61-67.
12. Toscano LT, Toscano LT, Tavares RL, da Silva CSO, Silva AS. Chia induces clinically discrete weight loss and improves lipid profile only in altered previous values. Nutr Hosp. 2015; 31:1176-1182.
13. Al-Bishri WM. Favorable effects of flaxseed supplemented diet on liver and kidney functions in hypertensive Wistar rats. J Oleo Sci. 2013; 62:709-715.
14. Hussein SA, El-Senosi YA, Ragab MR, Hammad MM. Beneficial effect of flaxseed oil on lipid metabolism in high cholesterol diet fed rats. Banha Vet Med J. 2014; 27:290-301.
15. Guevara-Cruz M, Tovar AR, Aguilar-Salinas CA, Medina-Vera I, Gil-Zenteno L, Hernández-Viveros I, López-Romero P, Ordaz-Nava G, Canizales-Quinteros S, Guillen Pineda LE, Torres N. A dietary pattern including nopal, chia seed, soy protein, and oat reduces serum triglycerides and glucose intolerance in patients with metabolic syndrome. J Nutr. 2011; 142:64-69.
16. Parameshwari S, Nazni P. Fatty acid composition and hypolipidemic effect of roasted flaxseed powder. Int J Pharma Med Biol Sci. 2012; 1:150-158.
17. Zhang W, Wang X, Liu Y, Tian H, Flickinger B, Empie MW, Sun SZ. Dietary flaxseed lignan extract lowers plasma cholesterol and glucose concentrations in hypercholesterolemic subjects. Br J Nutr. 2008;99:1301-1309.
18. Kothari M, Jeyaraj S. Effect of chia seed supplementation on the anthropometric measurements and serum lipid profile in women with hypercholesterolemia. World J Pharm Res. 2016; 6:929-936.
19. Ayerza R, Coates W. Effect of dietary α-linolenic fatty acid derived from chia when fed as ground seed, whole seed and oil on lipid content and fatty acid composition of rat plasma. Ann Nutr Metab. 2007; 51:27-34.
20. Bernacchia R, Preti R, Vinci G. Chemical composition and health benefits of flaxseed. Austin J Nutr Food Sci. 2014; 2:1045-1050.
21. Da Silva CS, Kanaguchi G, de Arruda Monteiro CR, Feder D, Azzalis LA, Perazzo FAF, Maifrino LBM, Ornelas E, Rosa PCEP, Fonseca FLA. Biochemical parameters and Histomorphometric cardiac evaluation among Wistar rats treated with chia seed (Salvia hispanica L.): experimental model. Afr J Pharm Pharmacol. 2016; 10:95-100.
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