Screening of Secondary Metabolites and their Antimicrobial Activity in Centaurium erythraea

Authors

  • Mohsin Ali Hassni Department of Pathology, Aria Institute of Medical Sciences, Quetta, Pakistan; CASVAB, University of Balochistan, Quetta, Pakistan Author
  • Laraib Zia-ul-Qamar Department of Pathology, Aria Institute of Medical Sciences, Quetta, Pakistan Author
  • Muhammad Tariq Hasni Department of Orthopedic, Bolan Medical College, Quetta, Pakistan Author
  • Khan Muhammad Babar Department of Surgery, Bolan Medical College, Quetta, Pakistan Author
  • Abdul Aleem Department of Pathology, Bolan Medical College, Quetta, Pakistan; CASVAB, University of Balochistan, Quetta, Pakistan Author
  • Muhammad Din Kakar Department of Pathology, Bolan Medical College, Quetta, Pakistan Author
  • Muhammad Sajid Hasni Department of Nursing & Allied Health Sciences, Alhamd Islamic University, Quetta, Pakistan Author
  • M. Siraj Saif Department of Pathology, Sheikh Mohamed Bin Zayed Al Nahyan Institute of Cardiology, Quetta, Pakistan Author
  • Zia U Din Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan Author

DOI:

https://doi.org/10.31580/g3h57255

Keywords:

Centaurium erythraea, Balochistan, Evaluation, Kech, Secondary Metabolites, Therapeutic benefits

Abstract

Centaurium erythraea, commonly known as Centaury, is found in the hot and arid regions of Balochistan, such as Turbat and other areas of Kech. Widely used as a medicinal herb in many parts of Europe, Centaury is often prepared as a tisane and is believed to offer therapeutic benefits, particularly for gastric and liver-related ailments. This plant contains a variety of secondary metabolites, including tannins, saponins, and reducing sugars, which are valuable in the medicine and pharmaceutical industries.

In this research, it was demonstrated that Centaury also exhibits antimicrobial activity. It is effective against gram-negative bacteria like E. coli, and gram-positive bacteria such as S. aureus, and shows limited activity against Bacillus species. Given its medicinal properties, Centaury holds potential for use in therapeutic industries. Furthermore, it contributes to advancements in drug development and offers insights into plant ecology and evolution

References

Alam MN, Bristi NJ, Rafiquzzaman M. Review on in vivo and in vitro methods evaluation of antioxidant activity. Saudi pharmaceutical journal. 2013;21(2):143-52.

Beerhues L, Berger U. Differential accumulation of xanthones in methyl-jasmonate-and yeast-extract-treated cell cultures of Centaurium erythraea and Centaurium littorale. Planta. 1995;197(4):608-12.

Beg ZH, Stonik JA, Brewer Jr HB. 3-Hydroxy-3-methylglutaryl coenzyme A reductase: regulation of enzymatic activity by phosphorylation and dephosphorylation. Proceedings of the National Academy of Sciences. 1978;75(8):3678-82.

Blanco JA, Imbert JB, Castillo FJ. Thinning affects Pinus sylvestris needle decomposition rates and chemistry differently depending on site conditions. Biogeochemistry. 2011;106:397-414.

Božunović J, Živković S, Gašić U, Glamočlija J, Ćirić A, Matekalo D, Šiler B, Soković M, Tešić Ž, Mišić D. In vitro and in vivo transformations of Centaurium erythraea secoiridoid glucosides alternate their antioxidant and antimicrobial capacity. Industrial crops and products. 2018;111:705-21.

Budniak L, Slobodianiuk L, Marchyshyn S, Klepach P. Investigation of the influence of the thick extract of common centaury (Centaurium erythraea Rafn.) herb on the secretory function of the stomach. diabetes. 2021;25:27.

Cheenpracha S, Jitonnom J, Komek M, Ritthiwigrom T, Laphookhieo S. Acetylcholinesterase inhibitory activity and molecular docking study of steroidal alkaloids from Holarrhena pubescens barks. Steroids. 2016;108:92-8.

Đorđević M, Mihailović M, Jovanović JA, Grdović N, Uskoković A, Tolić A, Sinadinović M, Rajić J, Mišić D, Šiler B, Poznanović G. Centaurium erythraea methanol extract protects red blood cells from oxidative damage in streptozotocin-induced diabetic rats. Journal of ethnopharmacology. 2017;202:172-83.

Jensen SR, Schripsema J. Chemotaxonomy and pharmacology of Gentianaceae. In Gentianaceae-systematics and natural history. Cambridge University Press. 2002:573-631.

Joseph B, Jini D. Antidiabetic effects of Momordica charantia (bitter melon) and its medicinal potency. Asian pacific journal of tropical disease. 2013;3(2):93-102.

Maguilla E, Escudero M, Jiménez-Lobato V, Díaz-Lifante Z, Andrés-Camacho C, Arroyo J. Polyploidy expands the range of Centaurium (Gentianaceae). Frontiers in Plant Science. 2021;12:650551.

Marahatha R, Basnet S, Bhattarai BR, Budhathoki P, Aryal B, Adhikari B, Lamichhane G, Poudel DK, Parajuli N. Potential natural inhibitors of xanthine oxidase and HMG-CoA reductase in cholesterol regulation: in silico analysis. BMC complementary medicine and therapies. 2021;21:1-1.

Matekalo D, Skorić M, Nikolić T, Novaković L, Lukić M, Božunović J, Aničić N, Filipović B, Mišić D. Organ-specific and genotype-dependent constitutive biosynthesis of secoiridoid glucosides in Centaurium erythraea Rafn, and its elicitation with methyl jasmonate. Phytochemistry. 2018;155:69-82.

Meelaph T, Kobtrakul K, Chansilpa NN, Han Y, Rani D, De-Eknamkul W, Vimolmangkang S. Coregulation of biosynthetic genes and transcription factors for aporphine-type alkaloid production in wounded lotus provides insight into the biosynthetic pathway of nuciferine. ACS omega. 2018;3(8):8794-802.

Rai AN, Vargas ML, Wang L, Andersen EF, Miller EL, Simon JA. Elements of the polycomb repressor SU (Z) 12 needed for histone H3-K27 methylation, the interface with E (Z), and in vivo function. Molecular and cellular biology. 2013;33(24):4844-56.

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Published

2024-12-28

How to Cite

Screening of Secondary Metabolites and their Antimicrobial Activity in Centaurium erythraea. (2024). Pak-Euro Journal of Medical and Life Sciences, 7(Special 2), S255-S262. https://doi.org/10.31580/g3h57255

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