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Abstract
Introduction: Aloe Vera (A. Vera) is commonly known as “Medicinal Aloe” has been reported to have antihyperglycemic potentials.
Objective: The examination of antihyperglycemic potential of A. Vera in diabetes induced models of rats.
Materials and Methodology: Healthy male Sprague-Dawley rats (n=25) 7 weeks old were used in experiments. Our experiemtal rats were 25 by numbers being divided in the five designated groups. The Group I (Control Group, Non-induced physiological rats), Group II (diabetes induced rats) III and IV (diabetes induced rats with A. Vera extract treatment). Except control of non-induced rats (Group I), Diabetes was induced in groups II, III, IV and V by Streptozotocin (STZ) intraperitoneal injections (200mg/kg). Following diabetes induction group III, IV and V were administered with the crude powder extract of A. Vera 1.5 g, 3.0 g and 4.5g respectively by mixing in diet, rats were given treatment of A. Vera for the period of 24 days. Metabolic hormones (thyroid hormones) and cortisol serum levels were measured by commercially available ELISA Kits in an automated chemiluminiscence Immunoassay CLIA analyzer. Data was analyzed by one-way ANOVA using SPSS 28.
Results: Results showed that treatment with Medicinal Aloe have highly significant effects. Among T3 and T4 and cortisol, T3 and cortisol levels were highly significant.
Conclusion: Aloe Vera has anti-hyperglycemic capacity and has variable effects on hormonal dynamics.
References
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