Managing Paronychia: Risk Factors, Symptoms and Treatment Approaches

----Review Article----

Authors

  • Bilal Javed Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan Author
  • Muhammad Kamran Taj Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan Author
  • Saad Ullah Jan Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan Author
  • Imran Taj Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan Author
  • Masroora Ali Khan Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan; Department of Microbiology, Sardar Bahadur Khan Women’s University (SBKWU), Quetta, Pakistan Author
  • Aroosa Akram Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan Author
  • Bibi Sazain Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan Author
  • Saima Azam Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan Author
  • Sabir Khan Panezai Education Department, Quetta, Balochistan, Pakistan Author
  • Sakina Khan Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan Author

DOI:

https://doi.org/10.31580/bj6d3z05

Keywords:

Common, Infection, Management, Paronychia, Risk factors

Abstract

Paronychia, a prevalent nail infection, is characterized by erythema and edema in the lateral nail fold, exhibiting acute or prolonged manifestations with infectious or noninfectious origins. Various causal agents, including Staphylococcus aureus and Candida albicans, have been identified through bacterial investigations. Immunocompromised individuals, diabetics, and those regularly exposed to chemicals and moisture are at an elevated risk for paronychia. Additionally, certain medications, such as epidermal growth factor receptor inhibitors, can induce paronychia. Occupations involving frequent mechanical trauma, like cooks and housekeepers, are particularly susceptible.

The condition is influenced by several risk factors, including age and participation in manicures. Staphylococcus aureus is the primary pathogen in bacterial paronychia, although fungal infections, irritants, nail-biting, and certain medications can also contribute. Complications may lead to the development of felons, and differential diagnoses encompass sclerotic cell cancer, onychomycosis, and cellulitis. Management options range from antibiotics and drainage to conservative measures, with surgery being reserved for rare and severe cases. Laser therapy presents an innovative therapeutic approach. Timely intervention and an understanding of risk factors are pivotal for the effective treatment of paronychia.

References

Lee DK, Lipner SR. Optimal diagnosis and management of common nail disorders. Annals of Medicine. 2022;54(1):694-712.

Rabarin F, Jeudy J, Cesari B, Petit A, Bigorre N, Saint-Cast Y, Fouque PA, Raimbeau G. Acute finger-tip infection: management and treatment. A 103-case series. Orthopaedics & Traumatology: Surgery & Research. 2017;103(6):933-6.

Nenoff P, Paasch U, Handrick W. Infections of finger and toe nails due to fungi and bacteria. Der Hautarzt. 2014;65:337-48.

Relhan V, Goel K, Bansal S, Garg VK. Management of chronic paronychia. Indian Journal of Dermatology. 2014;59(1):15.

Tosti A, Piraccini BM, Ghetti E, Colombo MD. Topical steroids versus systemic antifungals in the treatment of chronic paronychia: an open, randomized double-blind and double dummy study. Journal of the American Academy of Dermatology. 2002;47(1):73-6.

Shafritz AB, Coppage JM. Acute and chronic paronychia of the hand. JAAOS-Journal of the American Academy of Orthopaedic Surgeons. 2014;22(3):165-74.

Vandervall K, Yehl MA, Tjiattas-Saleski L. Paronychia. Osteopathic Family Physician. 2018;10(1).

Barger J, Garg R, Wang F, Chen N. Fingertip infections. Hand Clinics. 2020;36(3):313-21.

Rockwell PG. Acute and chronic paronychia. American family physician. 2001; 63(6):1113.

Chanprapaph K, Vachiramon V, Rattanakaemakorn P. Epidermal growth factor receptor inhibitors: a review of cutaneous adverse events and management. Dermatology research and practice. 2014;2014.

Bilolikar VK, Seigerman DA, Ilyas AM. Diagnosis and management of common hand infections. JBJS reviews. 2020;8(4):e0188.

Shemer A, Daniel III CR. Common nail disorders. Clinics in Dermatology. 2013;31(5):578-86.

Iorizzo M, Pasch MC. Bacterial and viral infections of the nail unit. Dermatologic Clinics. 2021;39(2):245-53.

Mukhtar M. Therapeutic Pearl: Use of Cyanoacrylate Glue for Treating Chronic Discharging Proximal Lateral Toenail Paronychia. Modern Care Journal. 2022;19(3).

Gupta AK, Versteeg SG, Shear NH. Onychomycosis in the 21st century: an update on diagnosis, epidemiology, and treatment. Journal of cutaneous medicine and surgery. 2017;21(6):525-39.

Rerucha CM, Ewing JT, Oppenlander KE, Cowan WC. Acute hand infections. American Family Physician. 2019;99(4):228-36.

Daniel CR, Daniel MP, Daniel J, Sullivan S, Bell FE. Managing simple chronic paronychia and onycholysis with ciclopirox 0.77% and an irritant-avoidance regimen. Cutis. 2004;73(1):81-5.

Algazaq J, Kamboj M, Babady NE. An infant with nasal vestibulitis and paronychia. Pediatric Dermatology. 2023.

Sigurgeirsson B, Steingrimsson O. Risk factors associated with onychomycosis. Journal of the European Academy of Dermatology and Venereology. 2004:18(1):48-51.

Russo TA, Marr CM. Hypervirulent klebsiella pneumoniae. Clinical microbiology reviews. 2019;32(3):10-128.

Jung JY, Choi YS, Yoon MY, Min SU, Suh DH. Comparison of a pulsed dye laser and a combined 585/1,064‐nm laser in the treatment of acne vulgaris. Dermatologic surgery. 2009;35(8):1181-7.

Alessandrini A, Bruni F, Starace M, Piraccini BM. Periungual pyogenic granuloma: The importance of the medical history. Skin appendage disorders. 2016;1(4):175-8.

Mustafa O, Althakafi S, Kattan S, Kattan M, AlHathal N. Scrotal abscess precipitating late infection of a malleable penile prosthesis: the risk never evanesces. Case reports in urology. 2016 Feb 4;2016.

Boucher KW, Davidson K, Mirakhur B, Goldberg J, Heymann WR. Paronychia induced by cetuximab, an antiepidermal growth factor receptor antibody. Journal of the American Academy of Dermatology. 2002;47(4):632-3.

Tomková H, Kohoutek M, Zábojníková M, Pospíšková M, Ostřížková L, Gharibyar M. Cetuximab‐induced cutaneous toxicity. Journal of the European Academy of Dermatology and Venereology. 2010;24(6):692-6.

Liu T, Jiang S, Teng X, Zhong L, Liu M, Jin Y, Dong M. A comparison of panitumumab and cetuximab in the treatment of KRAS wild-type metastatic colorectal cancer: a systematic review and meta-analysis. Immunopharmacology and Immunotoxicology. 2023;45(1):1-9.

Eekhof JA, Van Wijk B, Neven AK, van der Wouden JC. Interventions for ingrowing toenails. Cochrane database of systematic reviews. 2012(4).

Levi LI, Barbut F, Chopin D, Rondeau P, Lalande V, Jolivet S, Badell E, Brisse S, Lacombe K, Surgers L. Cutaneous diphtheria: three case-reports to discuss determinants of re-emergence in resource-rich settings. Emerging microbes & infections. 2021;10(1):2300-2.

Ohmori T, Yamaoka T, Ando K, Kusumoto S, Kishino Y, Manabe R, Sagara H. Molecular and clinical features of EGFR-TKI-associated lung injury. International Journal of Molecular Sciences. 2021;22(2):792.

Chang RM, Hare AQ, Rich P. Treating cosmetically induced nail problems. Dermatologic Therapy. 2007;20(1):54-9.

Wollina U. Systemic drug-induced chronic paronychia and periungual pyogenic granuloma. Indian Dermatology Online Journal. 2018;9(5):293.

Sibaud V, Casassa E, D’Andrea M. Are topical beta-blockers really effective “in real life” for targeted therapy-induced paronychia. Supportive Care in Cancer. 2019;27(7):2341-3.

Malay DS. How to address nail bed injuries. Podiatry Today. 2006;19(1).

Allouni A, Yousif A, Akhtar S. Chronic paronychia in a hairdresser. Occupational medicine. 2014;64(6):468-9.

Ho PH, Lin IC, Yang X, Cho YT, Chu CY. Using a novel scoring system for paronychia related to oncologic treatments (SPOT) for assessing paronychia severity and its correlation with pain index and quality of life. Journal of the European Academy of Dermatology and Venereology. 2019;33(1):204-12.

Durdu M, Ruocco V. Clinical and cytologic features of antibiotic-resistant acute paronychia. Journal of the American Academy of Dermatology. 2014;70(1):120-6.

Sun Q, Antaya RJ. Treatment of MEK inhibitor‐induced paronychia with doxycycline. Pediatric Dermatology. 2020;37(5):970-1.

Muti HY, Olimat S. HPLC Method of Analysis for Determination and Standardization of Luteolin and Vanillic acid in Dry Extract of Paronychia argentea Lam. Oriental Journal of Chemistry. 2018;34(6):2721.

Pilot MA, Bell C, O’Dair H, Glenn EJ, Bailey S, Langley-Hobbs SJ. Chronic paronychia in cats with patellar fracture and dental anomaly syndrome. Journal of Feline Medicine and Surgery. 2021;23(12):1200-12.

Robert C, Sibaud V, Mateus C, Verschoore M, Charles C, Lanoy E, Baran R. Nail toxicities induced by systemic anticancer treatments. The Lancet Oncology. 2015;16(4):e181-9..

Piraccini BM, Bellavista S, Misciali C, Tosti A, De Berker D, Richert B. Periungual and subungual pyogenic granuloma. British journal of dermatology. 2010;163(5):941-53.

Califano R, Tariq N, Compton S, Fitzgerald DA, Harwood CA, Lal R, Lester J, McPhelim J, Mulatero C, Subramanian S, Thomas A. Expert consensus on the management of adverse events from EGFR tyrosine kinase inhibitors in the UK. Drugs. 2015;75:1335-48.

Patel DB, Emmanuel NB, Stevanovic MV, Matcuk Jr GR, Gottsegen CJ, Forrester DM, White EA. Hand infections: anatomy, types and spread of infection, imaging findings, and treatment options. Radiographics. 2014;34(7):1968-86.

Stevens DL, Bisno AL, Chambers HF, Dellinger EP, Goldstein EJ, Gorbach SL, Hirschmann JV, Kaplan SL, Montoya JG, Wade JC. Practice guidelines for the diagnosis and management of skin and soft tissue infections: 2014 update by the Infectious Diseases Society of America. Clinical infectious diseases. 2014;59(2):e10-52.

Mohanan S, Rasheed N, KS BR. Formulation and evaluation of antimicrobial gels for the treatment of paronychia. International Journal of Applied Pharmaceutics. 2018:161-7.

Rubright JH, Shafritz AB. The herpetic whitlow. Journal of Hand Surgery. 201;36(2):340-2.

Santos LM, Santos JL, Guerra JA. Chronic paronychia as a manifestation of skin leishmaniasis. Revista da Sociedade Brasileira de Medicina Tropical. 2021;54.

Cardenas-de la Garza JA, Cuellar-Barboza A, Ancer-Arellano J, Cruz-Gomez LG, Villarreal-Villarreal CD, Gallardo-Rocha A, Vera-Cabrera L, Vazquez-Martinez O, Ocampo-Candiani J, Welsh O. Paronychia and Target Lesions After Hematopoietic Cell Transplant. Cutis. 2020;106(4):168-79.

WANG J, ZHAO M. Clinical study of Shiwei-Jinhuang Ointment and Chinese herbal external washing prescription for acute paronychia. International Journal of Traditional Chinese Medicine. 2021:138-41.

Hetterschijt CR, Pasch MC. Nail disorders in daily practice. Nederlands Tijdschrift Voor Geneeskunde. 2022;166:D6766-.

Saraswat N, Sood A, Verma R, Kumar D, Kumar S. Nail changes induced by chemotherapeutic agents. Indian Journal of Dermatology. 2020;65(3):193.

Naouri M, Mazer JM. Finger onychomycosis due to Candida tropicalis: short-pulsed Nd: YAG laser therapy. InAnnales de Dermatologie et de Venereologie 2013;140( 10): 610-613.

Xu LY, Wright DR, Mahmoud BH, Ozog DM, Mehregan DA, Hamzavi IH. Histopathologic study of hidradenitis suppurativa following long-pulsed 1064-nm Nd: YAG laser treatment. Archives of dermatology. 2011;147(1):21-8.

t response to cold stress in two oil plants of the genus Jatropha. Plant Soil Environ., 2017; 63:271-276.

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Published

2023-06-30

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Review Article

How to Cite

Managing Paronychia: Risk Factors, Symptoms and Treatment Approaches: ----Review Article----. (2023). Pak-Euro Journal of Medical and Life Sciences, 6(2), 145-154. https://doi.org/10.31580/bj6d3z05

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