Determination of the Frequency of Thyroid Dysfunction in Primary Infertile Women with Menstrual Irregularities
DOI:
https://doi.org/10.31580/pjmls.v4i1.1620Keywords:
Thyroid hormone, Menstrual irregularities, Primary infertility, Hypothyroidism, HyperthyroidismAbstract
Thyroid disease is the second most common endocrine condition in women of childbearing age and common endocrine disorders worldwide with females having infertility.1,2,3 The prevalence of infertility in Pakistan is 21.9% where, primary infertility is 3.9%, while prevalence of thyroid disorders in infertile women is variable globally.
Total 67 Primary infertile patients of age between 15- 35 years were included. A 3ml blood was sent laboratory for serum TSH, Free T3,
Patient with the following values above or below were considered as abnormal thyroid function i.e. TSH 0.35-5.50mU/L, Free T3 0.9-2.8pmol/L, Free T4 10.5-20pmol/L.
There were total 67 primary infertile patients aged between 15 to 35 years were included. Mean age was 26.88±3.898 years. Around 32 (47.8%) have BMI of >27 while 35 (52.2%) patients were having BMI 0f <27. No significant association found between smoking and thyroid dysfunction. 37 (55.20%) of total have thyroid dysfunction. Hypothyroidism with Menorrhagia was common i.e. 8 (11.8%). Obesity and menstrual irregularities have significant association with thyroid dysfunction with the (p=0.001 and p=0.011) respectively. While no significant (i.e. p=0.556 and 0.508) association with age and smoking was observed.
Our study showed, patients have complained of primary infertility with menorrhagia have high percentage of hypothyroidism, while patients had a history of infertility with amenorrhea had hyperthyroidism in common.
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