Integrated Molecular, Regenerative and Technological Innovations in the Modern Management of Diabetic Peripheral Neuropathy Review Article
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Abstract
By combining molecular, regenerative, and technological advancements, the treatment of diabetic peripheral neuropathy (DPN) is moving away from insufficient symptomatic pain relief and towards disease-modifying approaches. This all-encompassing method critically investigates pharmacological agents such as novel ion channel modulators for selective pain control and Mitochondria-Targeted Antioxidants (MTAs) to fight metabolic stress. Along with individualized lifestyle interventions like supervised exercise to increase IENF density and AI-driven precision nutrition, it also integrates state-of-the-art regenerative techniques, such as the paracrine effects of MSC-derived exosomes and the creation of smart biomaterial scaffolds for guided axonal repair. The review creates a vital framework for multi-modal, neuroprotective, and regenerative approaches that are critical for greatly enhancing functional outcomes and quality of life for DPN patients by bridging these disparate fields.
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