Isolation of Pathogenic Bacteria of Urinary Tract Infections and Their Antibiotic Sensitivity in Children Research Article
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Abstract
Urinary tract infections (UTIs) remain the most common bacterial disease in children. This cross-sectional study investigated the distribution and antibiotic susceptibility of uropathogens isolated from 85 pediatric patients (aged 2–10 years) in the Swat District, Pakistan. Escherichia coli was the predominant isolate (71.21%), followed by Enterococcus faecalis (20.31%) and Pseudomonas aeruginosa (6.06%), with infections occurring more frequently in females. Disk-diffusion testing interpreted according to Clinical and Laboratory Standards Institute (CLSI 2023) guidelines showed that E. coli isolates were highly susceptible to Meropenem (100%) and Tazocin (93.61%), whereas complete resistance was observed to Doxycycline, Amoxicillin-clavulanate, and Trimethoprim-sulfamethoxazole. Similar resistance patterns were found for E. faecalis and P. aeruginosa. These findings highlight the growing problem of multidrug-resistant pediatric uropathogens and support the empirical use of Meropenem or Tazocin as effective first-line therapies in this region. Continuous regional surveillance is recommended to guide antibiotic stewardship and reduce resistance development.
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