Epidemiological Investigation of Hepatitis C in Educational Institutes of Quetta City, Pakistan Research Article

Main Article Content

Zainab Noor Ahmed
Nargis Haider
Hasina Wali
Fazal ur Rahman
Muhammad Shafee
Heba Nadeem
Shabbir Ahmad Khan

Abstract

Globally, hepatitis C virus infection is a serious public health concern. About 157 million cases, with 71 million as chronic infections, as per a recent World Health Organization report. This study highlights the prevalence of HCV in various educational institutes in Quetta, Balochistan. A total of 400 samples were screened using the ICT kit, which were further confirmed by qPCR. The study encompassed diverse demographics, including gender, age groups, cultural backgrounds, and educational levels, offering critical insights into potential risk factors such as surgical history and blood transfusions of the subjects. Results revealed that among 400 serum samples collected from colleges in Quetta, 07/400 (1.75%) tested positive for HCV using ICT kits. Whereas, 5/400 (1.25%) were confirmed by qPCR. The majority of samples, 300 (75%) were from individuals aged 15-25 Years, with higher prevalence in females, 250/400 (63%), than males, 150/400 (37%). This study warns policymakers to initiate an awareness campaign in educational institutions to promote proper hygienic practices that will ultimately lead to minimize possible transmission risks.

Article Details

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Research Article

How to Cite

Epidemiological Investigation of Hepatitis C in Educational Institutes of Quetta City, Pakistan: Research Article. (2025). Pak-Euro Journal of Medical and Life Sciences, 8(3), 517-526. https://doi.org/10.31580/pjmls.v8i3.3283

References

Zelenev A, Li J, Shea P, Hecht R, Altice FL. Modeling combination hepatitis C virus treatment and prevention strategies in a network of people who inject drugs in the United States. Clinical Infectious Diseases. 2021 Mar 1;72(5):755-63.

Cozzani E, Herzum A, Burlando M, Parodi A. Cutaneous manifestations of HAV, HBV, HCV. Italian Journal of dermatology and venereology. 2019 Dec 4;156(1):5-12.

Audu RA, Okwuraiwe AP, Ige FA, Onyekwere CA, Lesi OA, Adeleye OO. Hepatitis C viral load and genotypes among Nigerian subjects with chronic infection and implication for patient management: a retrospective review of data. Pan African Medical Journal. 2020 Dec 10;37(1).

Ochei, K.C.; Obeagu, E.I.; Ibegi, B.T.; Ugobo, E.I.; Odu, M.. Prevalence of hepatitis B and C from samples received from the various wards in Niger Delta University Teaching Hospital (NDUTH), Okolobiri for Hematological analyses. Merit Res. J., 2016, 4(4), 204-209.

Ekpenyong M, Tawari-ikeh P, Ekpenyong A. Investigation on the awareness of hepatitis B virus among health care workers in Nigeria. Nursing and Palliative Care. 2016 Oct 28;1(5):124-9.

Kashif M, Zaman F, Uzman MH, Shabbir T, Khan NU, Atta S, Shiraz S, Zahid MA, Munir A. Prevalence of Hepatitis C in Liver Cirrhosis Patients: HCV Prevalence in Cirrhosis Patients. Journal of Health and Rehabilitation Research. 2024 Sep 18;4(3):1-4.

Zulfiqar A, Iqbal T, Munir A. Machine Learning-Based Classification Algorithms for Predicting Hepatitis C: A Comprehensive Analysis. Journal of Computing & Biomedical Informatics. 2024 Oct 28;8(01).

Shahid I, Alzahrani AR, Al-Ghamdi SS, Alanazi IM, Rehman S, Hassan S. Hepatitis C diagnosis: simplified solutions, predictive barriers, and future promises. Diagnostics. 2021 Jul 13;11(7):1253.

Henrietta P. Antiviral activity evaluation of pharmaceutical drugs, newly synthesized compounds and fragments against SARS-CoV-2 in vitro.

Elahimanesh Z, Bokharaei-Salim F, Donyavi T, Monavari SH, Tavakoli A, Khoshmirsafa M, Chavoshpour S, Abbasi-Kolli M, Ghalejoogh ZY, Kiani SJ. Prevalence of Hepatitis C Virus and Human Pegivirus Type 1 Co-Infection in Patients Infected with Human Immunodeficiency Virus Type-1. Prevalence. 2024 Dec 30;30(3):53-8.

Germer JJ, Harmsen WS, Mandrekar JN, Mitchell PS, Yao JD. Evaluation of the COBAS TaqMan HCV test with automated sample processing using the MagNA pure LC instrument. Journal of clinical microbiology. 2005 Jan;43(1):293-8.

Umutesi J, Liu CY, Penkunas MJ, Makuza JD, Ntihabose CK, Umuraza S, Niyikora J, Serumondo J, Gupta N, Nsanzimana S. Screening a nation for hepatitis C virus elimination: a cross-sectional study on prevalence of hepatitis C and associated risk factors in the Rwandan general population. BMJ open. 2019 Jul 1;9(7):e029743.

Usman A, Kuta FA, Saidu TB, Shittu OK. Seroprevalence and risk factors of hepatitis C virus infection among blood donors attending selected hospitals in Kaduna State. Microbes and Infectious Diseases. 2024 Jan 24.

Puri P, Sharma PK, Nagpal AK. Viral hepatitis in India: armed forces perspective. medical journal armed forces india. 2016 Jul 1;72(3):201-3.

Alqahtani SA, Colombo M. Viral hepatitis as a risk factor for the development of hepatocellular carcinoma. Hepatoma Research. 2020 Sep 1;6:N-A.

Birku T, Gelaw B, Moges F, Assefa A. Prevalence of hepatitis B and C viruses infection among military personnel at Bahir Dar Armed Forces General Hospital, Ethiopia. BMC Res Notes. 2015;8(1):1–6. doi:10.1186/s13104-015-1719-2

Negash M, Ayalew M, Geremew D, Workineh M. Seroprevalence and associated risk factors for HIV, Hepatitis B and C among blood Donors in South Gondar District blood Bank, Northwest Ethiopia. BMC infectious diseases. 2019 Dec;19:1-0

Moossavi M, Bahrami A, Rasekh H, Naghizadeh MS, Abd H, Fereidouni M. The prevalence of hepatitis B, hepatitis C and human immunodeficiency viral infections among a large population of Afghans. Hepatitis Monthly. 2020 Jan 1;20(7).

Umumararungu E, Ntaganda F, Kagira J, Maina N. Prevalence of hepatitis C virus infection and its risk factors among patients attending Rwanda Military Hospital, Rwanda. BioMed research international. 2017;2017(1):5841272.

Centers for Disease Control and Prevention (CDC). (2012). Updated CDC recommendations for the management of hepatitis B virus-infected health-care providers and students. MMWR. Morbidity and Mortality Weekly Report., 2012, 61(RR 3):1-2.

Al-Rubaye A, Tariq Z, Alrubaiy L. Prevalence of hepatitis B seromarkers and hepatitis C antibodies in blood donors in Basra, Iraq. BMJ open gastroenterology. 2016 Jan 1;3(1):e000067.

Akhtar H, Badshah Y, Akhtar S, Hassan F, Faisal M, Qadri I. Prevalence of hepatitis B and hepatitis C Virus infections among male to female (MFT) transgenders in Rawalpindi (Pakistan). Advancements in Life Sciences. 2018 Feb 25;5(2):46-55.

Ahmad I. Prevalence of hepatitis B and C viral infection among pregnant women in Peshawar, Pakistan. Hepatitis monthly. 2016 Jun 1;16(6):e36383.

Tanveer Z, Ahmad I, Javed MS, Malik SA, Kakar NH, Ahmad M, Patching SG, Naeem M, Mustafa MZ. Screening for hepatitis b and c viral infections among pregnant women attending the Bolan Medical Complex Hospital and Sandeman Provincial Civil Hospital Quetta, Pakistan. The Professional Medical Journal. 2020 Jul 10;27(07):1328-34.

Babiker A, Hassan M, Muhammed S, Taylor G, Poonia B, Shah A, Bagchi S. Inflammatory and cardiovascular diseases biomarkers in chronic hepatitis C virus infection: A review. Clinical cardiology. 2020 Mar;43(3):222-34.

Ahmed S, Baloch MA. Analysing the Socio-economic Factors Causing Hepatitis B and C in Baluchistan A Case Study of Quetta District. Pakistan Study Centre. 2017 Jun 29;5(1):235-50.

Saleem U, Aslam N, Siddique R, Iqbal S, Manan M. Hepatitis C virus: Its prevalence, risk factors and genotype distribution in Pakistan. European Journal of Inflammation. 2022 Nov 30;20:1721727X221144391.

Khan B, Iqbal A, Baloch MC, Ismail M, Nasir S, Iqbal B, Naseem M. Screening of Risk Factors and Subclinical Aspects for Hepatitis A, B and C in the Hospitalized Drug Addictives in “Treatment And Rehabilitation Center” in District Kech, Baluchistan. Pak-Euro Journal of Medical and Life Sciences. 2023 Jun 30;6(2):77-84.

Cui F, Faini D, Razavi-Shearer D, Razavi H, Manzengo Mingiedi C, Alonso Gonzalez M, Alaama AS, Mozalevskis A, Chan P, Izumi K, Ghrabi MA. Global Hepatitis Burden–Data for Action on Access of a Leading Infectious Disease Burden.

Memon GR, Siyal AR, Pathan MI, Shah IU. Comparison of Immunochromatography test (ICT) with real time polymerase chain reaction (RT–PCR) in detection of HCV. JMMC. 2016;7(2):21-3.