Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae in a Tertiary Care Teaching Hospital In Islamabad and their Antimicrobial Susceptibility Pattern
DOI:
https://doi.org/10.31580/pjmls.v6i3.3017Keywords:
Common flora, Enterobacteriaceae, Extended-spectrum beta-lactamase, ESBL, Gram negative, PathogenAbstract
Enterobacteriaceae that produce extended-spectrum beta-lactamases pose a serious threat to public health. The rising rate of antimicrobial resistance caused by ESBL-producing Enterobacteriaceae is leading to treatment failure and economic burden on the Health System. This study aimed to determine the prevalence of Enterobacteriaceae that produce extended spectrum beta lipotoxins (ESBLs), the most common bacterial isolates from different clinical samples, and their antimicrobial susceptibility profile in a tertiary care hospital.
Materials and Methods: The study was carried out in the Microbiology section and was a retrospective descriptive cross-sectional study. In the Pathology Department of Dr. Akbar Niazi Teaching Hospital, Islamabad from July 2022 to December 2021. A total of 206 strains of Enterobacteriaceae isolated from different clinical specimens were included by non-probability convenient sampling technique.
Results: Our results showed that the frequency of ESBL-producing isolates was 29.6% in our setup. The majority of the samples were received from the age group 61-70 years followed by the age group 31-40 years (16.4%), 51-60 years (14.8%), and 71-80 years (14.8%). Out of 61 positive isolates, most of them were from males (50.8%) than females (49.2%). The most common sample from which ESBL-producing isolates were obtained was urine (44.3%) followed by pus (21.3%). E. coli was the maximum common ESBL-producing pathogen (85.2%) followed by Klebsiella pneumoniae (11.5%).
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