Effects of Pregablin Vs Gabapentin on Pain Intensity in Patients with Chronic Sciatica in Bolan Medical Complex Hospital (BMCH), Quetta
Article Sidebar
Main Article Content
Abstract
Background: Sciatica is a challenging neuropathic pain disorder, and it is extremely difficult to treat it adequately. This trial aims to assess the effectiveness of gabapentin (GBP) and pregabalin (PGB) in treating sciatic pain.
Objective: To evaluate and compare the effectiveness of pregabalin (PGB) and gabapentin (GBP) in treating persistent sciatica.
Materials and methods: The study design was a prospective, double-blind, single-center, double-dummy randomized, cross-over in patients with chronic sciatica. The study was conducted at the Department of Neurology Bolan Medical Complex Hospital, Quetta. The study included 67 participants to explore the efficacy of GBP and PGB in sciatic pain. The Quebec Back Pain Scale and VAS were used to measure the efficacy of gabapentin (GBP) and pregabalin (PGB) in treating chronic sciatica adverse events, concurrent drug profiles, and demographic factors were evaluated.
Results: In this randomized control trial (n = 67), there was a significant improvement in functionality (GBP: Quebec Back Pain Scale 60.61 to 35.21, p <.003; PGB: Quebec Back Pain Scale 60.64 to 37.03, p <.001) and a significant reduction in pain (GBP: VAS 7.77 to 3.22, p <.012; PGB: VAS 7.82 to 3.46, p <.012). Gabapentin was found to be more effective (VAS difference: 3.22 vs. 3.46, p =.003; improvement on the Quebec Back Pain Scale: 35.21 vs. 37.03, p =.017). Adverse effects ranged; gabapentin showed increased vertigo/dizziness (9.68% vs. 6.45%) and pregabalin showed higher drowsiness (79.03% vs. 27.42%)
Conclusion: For persistent sciatica, gabapentin is a better option because it works better at reducing pain intensity. These results offer clinicians useful information for customizing neuropathic pain management approaches.
Article Details
Section
This work is licensed under a Creative Commons Attribution 4.0 International License.
How to Cite
References
Nisargandha M, Parwe SD, Wankhede SG, Deshpande VK. Comparison of nerve conduction studies on affected and non-affected side in the patients of sciatica. Int j basic appl physiol. 2020;9(1):1.
Kizaki K, Uchida S, Shanmugaraj A, Aquino CC, Duong A, Simunovic N, et al. Deep gluteal syndrome is defined as a non-discogenic sciatic nerve disorder with entrapment in the deep gluteal space: a systematic review. Knee Surgery, Sports Traumatology, Arthroscopy. 2020;28:3354-64.
Ropper AH, Zafonte RDJNEJoM. Sciatica. 2015;372(13):1240-8.
Fairag M, Kurdi R, Alkathiry A, Alghamdi Sr N, Alshehri RS, Alturkistany FO. Risk factors, prevention, and primary and secondary management of sciatica: an updated overview. 2022;14(11).
Furlong B, Etchegary H, Aubrey-Bassler K, Swab M, Pike A, Hall AJPo. Patient education materials for non-specific low back pain and sciatica: A systematic review and meta-analysis. 2022;17(10):e0274527.
Peul WC, Van Houwelingen HC, van den Hout WB, Brand R, Eekhof JA, Tans JT, et al. Surgery versus prolonged conservative treatment for sciatica. 2007;356(22):2245-56.
Hamoud Alotaibi A, Alanazi NM, Tinan Alenezi AA, Ahmed Abukanna AMJAJoM, Health. Overview of Causes, Risk Factors and Management of Sciatica: A Review. 2022:64-70.
Adoukonou T, Adogblé L, Agbétou M, donné Gnonlonfoun D, Houinato D, Ouendo E-M. Prevalence of the major neurological disorders in a semi-urban community in northern Benin. Eneurologicalsci. 2020;19:100242.
Clarisse J, Cotten A, Chastanet P, Singer B, Assaker R. Bilan radiologique d'une sciatique opérée et récidivante. Radiologie (Berlin). 1995;15(5):50-6.
Curraladas J. Enquête chez les lombo-sciatiques opérées. Kinésithérapie scientifique. 1996(361):2-3.
Saba Riaz PS, Islam A, Sadique A, Iqbal A, Afzal F. Neuromuscular diseases seen in District Head Quarters Hospital, Sargodha, Pakistan. Rawal Medical Journal. 2020;45(2).
Grøvle L, Hasvik E, Holst R, Haugen AJJT. NSAIDs in sciatica (NIS): study protocol for an investigator-initiated multicentre, randomized placebo-controlled trial of naproxen in patients with sciatica. 2022;23(1):493.
Saad EA, El Nouby FHH, El Fayomi G, Fehr AAE, Fathy NAJTEJoHM. Comparative study between mesotherapy and conventional systemic NSAIDs in the treatment of chronic low back pain with sciatica. 2019;74(7):1534-43.
Aguilar-Shea AL, Gallardo-Mayo C, Sanz-González R, Paredes IJJoFM, Care P. Sciatica. Management for family physicians. 2022;11(8):4174-9.
Araya EI, Gambeta E, Lejeune VB, Turnes JM, Jesus CH, Chichorro JGJFiCDR-C, et al. Chronic Pain: Focus on Anticonvulsants. 2022;10:269.
Javed S, Abdi SJPM. Use of anticonvulsants and antidepressants for treatment of complex regional pain syndrome: a literature review. 2021;11(2):189-99.
Nakashima H, Kanemura T, Ando K, Kobayashi K, Yoneda M, Ishiguro N, et al. Is pregabalin effective against acute lumbar radicular pain? 2019;3(1):61-6.
Ahmad N, Subhan F, Islam NU, Shahid M, Ullah N, Ullah R, et al. A novel gabapentin analogue assuages neuropathic pain response in chronic sciatic nerve constriction model in rats. 2021;405:113190.
Pinto Filho WA, Silveira LdHJ, Vale ML, Fernandes CR, Gomes JAJA, Medicine P. The effect of gabapentin on postoperative pain of orthopedic surgery of lower limb by sciatic and femoral blockage in children: a clinical trial. 2019;9(4).
Moher D, Chan AWJGfRHRausm. SPIRIT (standard protocol items: recommendations for interventional trials). 2014:56-67.
Tatit RT, Poetscher AW, Oliveira CACd. Pregabalin and gabapentin for chronic low back pain without radiculopathy: a systematic review. Arquivos de Neuro-Psiquiatria. 2023;81(06):564-76.
Giménez-Campos MS, Pimenta-Fermisson-Ramos P, Díaz-Cambronero JI, Carbonell-Sanchís R, López-Briz E, Ruíz-García V. A systematic review and meta-analysis of the effectiveness and adverse events of gabapentin and pregabalin for sciatica pain. Atencion primaria. 2022;54(1):102144.
Robertson KL. Pregabalin and gabapentin for the management of chronic sciatica: determining utility, effect on functioning capacity, quality of life and clinical outcome: James Cook University; 2018.
Mathieson S, Lin C-WC, Underwood M, Eldabe S. Pregabalin and gabapentin for pain. Bmj. 2020;369.
Baron R, Freynhagen R, Tölle TR, Cloutier C, Leon T, Murphy TK, et al. The efficacy and safety of pregabalin in the treatment of neuropathic pain associated with chronic lumbosacral radiculopathy. Pain. 2010;150(3):420-7.