Comparative Study to Evaluate Antibacterial Feed Additive and Probiotic on the Performance of Broiler Chicken

Authors

  • Shamsuddin Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan
  • Majed Rafeeq Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan
  • Irfan Shahzad Sheikh Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan
  • Rana Muhammad Bilal Department of Animal Nutrition, Cholistan University of Veterinary and Animal Sciences, Bhawalpur, Pakistan
  • Shujaat Hussain Faculty of Veterinary and Animal Sciences, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan
  • Muhammad Nadeem Faculty of Veterinary and Animal Sciences, Pir Mehr Ali Shah Arid Agriculture University, Rawalpindi, Pakistan
  • Asadullah Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan
  • Zia u Din Center for Advanced Studies in Vaccinology and Biotechnology (CASVAB), University of Balochistan, Quetta, Pakistan
  • Daud Khan Livestock and Dairy Development Department, Balochistan, Quetta, Pakistan and Center for Advanced Studies in Vaccinology and Biotechnology, University of Balochistan, Quetta, Pakistan

DOI:

https://doi.org/10.31580/j02c1y27

Keywords:

Broiler chicken, Growth, Probiotic, Zinc bacitracin

Abstract

The present study was carried out to evaluate the effect of antibiotic feed additives and probiotics on the productive performance of broiler chicken. For this purpose, 280-day-old broiler chicks were randomly divided into seven treatment groups. The birds were offered basal starter and finisher diet (Control) or the same basal diet supplemented with zinc bacitracin @ 250 and 500mg kg-1 (ZnB1 & ZnB2) alone and in combination (AB+ZnB1 & AB+ZnB2) with commercial blend of antibacterial feed additive (AB) 500mg kg-1; probiotic was offered to birds through gavage once every week @ 3x108cfu per bird. Supplementation of feed additives and probiotics improved the growth performance of broiler chicken in comparison to the control (P<0.05). Supplementation of ZnB1 and ZnB2 alone did not show better growth in comparison to the commercial blend of antibiotics; similarly combination of zinc bacitracin with antibiotic did not exhibit any additive effect (P>0.05). Feed consumption was noted significantly different among treatment groups (P<0.05). Haematological and serum biochemical parameters observed were noted as insignificant among treatment groups (P>0.05); however, minor numeric differences within normal ranges were present. In conclusion, the results of the present study suggest that the supplementation of antibacterial additive can improve the growth performance of broiler chickens and probiotics given through water can also be an option to replace antibacterial growth promoter feed additive.  

References

Hussain S, Malik S, Masud Cheema M, Ashraf MU, Waqas M, Iqbal M, Ali S, Anjum L, Aslam M, Afzal H. An overview on emerging water scarcity challenge in Pakistan, its consumption, causes, impacts and remedial measures. Big Data in Water Resources Engineering (BDWRE). 2020;1(1):22-31.

Choi J, Kim WK. Dietary application of tannins as a potential mitigation strategy for current challenges in poultry production: A review. Animals. 2020 Dec 14;10(12):2389.

Nasir Z, Grashorn MA. Alternatives to antibiotics: Do we really have some alternatives. InProceeding XXIII World's Poultry congress 2008. World's Poult. Sci. J. 64 (supplement 2), 165.

Rafeeq M, Rashid N, Tariq MM, Shahzad I, Sheikh MZ, Shafee M, Mehmood K, Bilal RM, Asmat T. Effect of herbal extract on the growth performance, serum biochemical composition, ileal histo-morphology and immune response of broiler chickens. Pak. J. Zool. 2021; 31(53):1793.

Dahiya JP, Wilkie DC, Van Kessel AG, Drew MD. Potential strategies for controlling necrotic enteritis in broiler chickens in post-antibiotic era. Animal Feed Science and Technology. 2006;129(1-2):60-88.

Steiner T, Syed B. Phytogenic feed additives in animal nutrition. Medicinal and aromatic plants of the world: Scientific, production, commercial and utilization aspects. 2015:403-23.

Marshall BM, Levy SB. Food animals and antimicrobials: impacts on human health. Clinical microbiology reviews. 2011;24(4):718-33.

Castanon JI. History of the use of antibiotic as growth promoters in European poultry feeds. Poultry science. 2007;86(11):2466-71.

Aslam B, Khurshid M, Arshad MI, Muzammil S, Rasool M, Yasmeen N, Shah T, Chaudhry TH, Rasool MH, Shahid A, Xueshan X. Antibiotic resistance: one health one world outlook. Frontiers in cellular and infection microbiology. 2021:1153.

Crisol-Martínez E, Stanley D, Geier MS, Hughes RJ, Moore RJ. Understanding the mechanisms of zinc bacitracin and avilamycin on animal production: linking gut microbiota and growth performance in chickens. Applied Microbiology and Biotechnology. 2017;101(11):4547-59.

Haghighi HR, Gong J, Gyles CL, Hayes MA, Zhou H, Sanei B, Chambers JR, Sharif S. Probiotics stimulate production of natural antibodies in chickens. Clinical and Vaccine Immunology. 2006;13(9):975-80.

Hassan A, Ali S, Farooq MA, Tahir HM, Awan MU, Mughal TA. Optimization of enhanced microbial production of zinc bacitracin by submerged fermentation technology. Journal of basic microbiology. 2020 ;60(7):585-99.

Page SW, Gautier P. Use of antimicrobial agents in livestock. Revue Scientifique et Technique-OIE. 2012;31(1):145.

Gautier EL, Shay T, Miller J, Greter M, Jakubzick C, Ivanov S, Helft J, Chow A, Elpek KG, Gordonov S, Mazloom AR. Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages. Nature immunology. 2012;13(11):1118-28.

Manyi-Loh C, Mamphweli S, Meyer E, Okoh A. Antibiotic use in agriculture and its consequential resistance in environmental sources: potential public health implications. Molecules. 2018;23(4):795.

Wu Y, Wang B, Zeng Z, Liu R, Tang L, Gong L, Li W. Effects of probiotics Lactobacillus plantarum 16 and Paenibacillus polymyxa 10 on intestinal barrier function, antioxidative capacity, apoptosis, immune response, and biochemical parameters in broilers. Poultry Science. 2019;98(10):5028-39.

Rahman MR, Fliss I, Biron E. Insights in the development and uses of alternatives to antibiotic growth promoters in poultry and swine production. Antibiotics. 2022;11(6):766.

Engberg RM, Hedemann MS, Leser TD, Jensen BB. Effect of zinc bacitracin and salinomycin on intestinal microflora and performance of broilers. Poultry science. 2000;79(9):1311-9.

Miles I. Knowledge intensive business services: prospects and policies. foresight. 2005;7(6):39-63.

Abudabos AM, Alyemni AH, Dafalla YM, Khan RU. Effect of organic acid blend and Bacillus subtilis alone or in combination on growth traits, blood biochemical and antioxidant status in broilers exposed to Salmonella typhimurium challenge during the starter phase. Journal of Applied Animal Research. 2017;45(1):538-42.

Kulkarni RR, Gaghan C, Gorrell K, Sharif S, Taha-Abdelaziz K. Probiotics as alternatives to antibiotics for the prevention and control of necrotic enteritis in chickens. Pathogens. 2022;11(6): 692.

Pickard JM, Zeng MY, Caruso R, Núñez G. Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease. Immunological reviews. 2017;279(1):70-89.

Didari T, Solki S, Mozaffari S, Nikfar S, Abdollahi M. A systematic review of the safety of probiotics. Expert opinion on drug safety. 2014;13(2):227-39.

Sugiharto S, Isroli I, Yudiarti T, Widiastuti E. The effect of supplementation of multistrain probiotic preparation in combination with vitamins and minerals to the basal diet on the growth performance, carcass traits, and physiological response of broilers. Veterinary World. 2018;11(2):240.

Thema K, Mlambo V, Snyman N, Mnisi CM. Evaluating alternatives to zinc-bacitracin antibiotic growth promoter in broilers: Physiological and meat quality responses. Animals. 2019; 9(12): 1160.

Letlole BR, Damen EP, Jansen van Rensburg C. The effect of α-monolaurin and butyrate supplementation on broiler performance and gut health in the absence and presence of the antibiotic growth promoter zinc bacitracin. Antibiotics. 2021;10(6): 651.

Attia YA, Bovera F, Abd El‐Hamid AE, Tag El‐Din AE, Al‐Harthi MA, El‐Shafy AS. Effect of zinc bacitracin and phytase on growth performance, nutrient digestibility, carcass and meat traits of broilers. Journal of Animal Physiology and Animal Nutrition. 2016;100(3):485-91.

Casewell M, Friis C, Marco E, McMullin P, Phillips I. The European ban on growth-promoting antibiotics and emerging consequences for human and animal health. Journal of antimicrobial chemotherapy. 2003 ;52(2):159-61.

Awad WA, Ghareeb K, Abdel-Raheem S, Böhm J. Effects of dietary inclusion of probiotic and synbiotic on growth performance, organ weights, and intestinal histomorphology of broiler chickens. Poultry science. 2009;88(1):49-56.

Feng, Y., Gong, J., Yu, H., Jin, Y., Zhu, J., & Han, Y. Identification of changes in the composition of ileal bacterial microbiota of broiler chickens infected with Clostridium perfringens. Veterinary microbiology. 2010: 140(1): 116-121.

Apajalahti, J., & Vienola, K. Interaction between chicken intestinal microbiota and protein digestion. Animal Feed Science and Technology. 2016; 221: 323-330.

Abdel-Raheem SM, Abd-Allah SM, Hassanein KM. The effects of prebiotic, probiotic and synbiotic supplementation on intestinal microbial ecology and histomorphology of broiler chickens. International Journal for Agro Veterinary and Medical Sciences. 2012;6(4):277-89.

Toghyani M, Toghyani M, Gheisari A, Ghalamkari G, Eghbalsaied S. Evaluation of cinnamon and garlic as antibiotic growth promoter substitutions on performance, immune responses, serum biochemical and haematological parameters in broiler chicks. Livestock science. 2011 Jun 1;138(1-3):167-73.

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Published

2023-09-30

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Vol. 6 No. 3 (2023): July-September

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