In-silico Identification and Characterization of Chemical Stress Responding Genes in Yeast (Saccharomyces cerevisiae)

Authors

  • Quratulain Qurban Department of Chemistry, Sardar Bahadur Khan Women’s University, Quetta, Pakistan
  • Farrukh Bashir Department of Chemistry, Sardar Bahadur Khan (SBK) Women’s University, Quetta-87300, Balochistan
  • Farida Bhelil Department of Chemistry, Sardar Bahadur Khan (SBK) Women’s University, Quetta-87300, Balochistan
  • Ayesha Mushtaq Department of Biochemistry, Sardar Bahadur Khan (SBK) Women’s University, Quetta-87300, Balochistan
  • Sabeena Rizwan Department of Biochemistry, Sardar Bahadur Khan (SBK) Women’s University, Quetta-87300, Balochistan
  • Musarat Riaz Department of Chemistry, Sardar Bahadur Khan (SBK) Women’s University, Quetta-87300, Balochistan
  • Zil-E-Huma Department of Zoology, Sardar Bahadur Khan Women’s University, Quetta, Pakistan
  • Huma Tareen Department of Chemistry, Sardar Bahadur Khan (SBK) Women’s University, Quetta-87300, Balochistan
  • Ismail Mazhar Combined Military Hospital Lahore Medical College and Institute of Dentistry-54590 Pakistan
  • Muhammad Aamir Raza Pakistan Council of Scientific and Industrial Research Laboratories Complex, Quetta-87300, Pakistan

DOI:

https://doi.org/10.31580/rxbke063

Keywords:

Chemical stresses, Computational Tool, Genes, Microarray, Ox idative Stress, Saccharomyces cerevisiae

Abstract

Saccharomyces cerevisiae (yeast) is treated as a model organism to study the life processes of all eukaryotes. Chemical stresses change the regulation of genes present in living organisms. To study the responses of genes at the transcription level, yeast is found to be the best model. The information obtained from the responses of genes, under chemical stresses provides a platform to formulate the mechanism and engineering strategies. These strategies will be helpful against the genes which are resistant to chemical stresses. Computational tools and data available on microarray are used to study the responses of genes in yeast under oxidative stresses, carbon dioxide and heme deficiency and hypoxia, and DNA damage stresses. 180 genes are identified out of 9335 genes of yeast nder these chemical stresses. Furthermore, these identified genes are characterized on
the basis of their molecular function, biological process and cellular components.

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Published

2023-09-30

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Vol. 6 No. 3 (2023): July-September

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