The Status of vitamin D in children with Nephrotic syndrome in outpatient nephrology department, children hospital PIMS
Status of vitamin D in children with Nephrotic syndrome
Keywords:Calcium metabolism, Clinical outcomes, Nephrotic syndrome, Pediatric, Vitamin D deficiency
AbstractThis cross-sectional study, conducted from January to June 2023 at the Department of Pediatrics Medicine, Children Hospital, PIMS Islamabad, aimed to determine the frequency of vitamin D deficiency in children diagnosed with nephrotic syndrome. A sample size of 180 cases was selected, with a 95% confidence level, 8% margin of error, and an expected vitamin D deficiency rate of 47.05%. Inclusion criteria included children aged 5-13 years with nephrotic syndrome, while exclusion criteria excluded recurrent vitamin D deficiency, GFR<70, vitamin supplement usage, and anti-epileptic medication. The study reveals that there is no strong correlation between the gender, age, weight and duration of nephrotic syndrome. Nevertheless, there are significant relationships among these factors and vitamin D deficiency. The children with age group 16-27 kg exhibited low chances of vitamin D deficiency as compared to the children in age group of 10-15 kg. Moreover, young children (4-8 years) were more susceptible to than older ones (9-13 years) and females are more liable to vitamin D deficiency than males. Risk estimates for hypocalcemia indicated minimal impacts of age, gender, and weight. The fiindings from this study accentuate that there is need of vigilant monitoring and tailored inventions, especially for younger children and females, to address vitamin D deficiency in nephrotic syndrome patients. Additionally, research is needed to explore fundamental mechanisms and assess targeted strategies for optimizing vitamin D status and overall health in this population.
Zolotas E, Krishnan RG. Nephrotic syndrome. Paediatrics and Child Health 2016;26(8):349-52.
Zhang X, Wu X, Wang F, Yi Z, Cao Y. Vitamin D levels and vitamin D receptor expression in children with primary nephrotic syndrome. BMC 2017 ;28 (21): 9658-62
Odaka J, Kanai T, Ito T, Saito T, Aoyagi J, Betsui H, et al. Apolipoprotein CI Levels Are Associated with the Urinary Protein/Urinary Creatinine Ratio in Pediatric Idiopathic Steroid-Sensitive Nephrotic Syndrome: A Case Control Study. International journal of nephrology 2017; Article ID 6392843
Yousefichaijan P, Eghbali A, Khosrobeigi A, Taherahmadi H, Rafiei M, Tayebi S, et al. Vitamin D status in children with nephrotic syndrome. Journal of Comprehensive Pediatrics 2018;9(3): e12403
Mazzaferro S, Goldsmith D, Larsson T, Massy Z, Cozzolino M. Vitamin D metabolites and/or analogs: which D for which patient? Current vascular pharmacology 2014;12(2):339-49.
Lang C-L, Wang M-H, Chiang C-K, Lu K-C. Vitamin D and the Immune System from the Nephrologist's Viewpoint. ISRN endocrinology 2014;2014: 105456.
Vanherwegen A-S, Gysemans C, Mathieu C. Vitamin D endocrinology on the cross-road between immunity and metabolism. Molecular and cellular endocrinology 2017;453:52-67.
Esmaeeili M, Azarfar A, Hoseinalizadeh S. Calcium and vitamin D metabolism in pediatric nephrotic syndrome; an update on the existing literature. International Journal of Pediatrics 2015;3(2.1):103-9.
Illalu S, Venkatareddy VS, Fattepur SR. Study of prevalence of vitamin D deficiency in nephrotic syndrome. International Journal of Contemporary Pediatrics 2019;6(2):288.
Selewski DT, Chen A, Shatat IF, Pais P, Greenbaum LA, Geier P, et al. Vitamin D in incident nephrotic syndrome: a Midwest Pediatric Nephrology Consortium study. Pediatric Nephrology 2016;31(3):465-72.
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