Helicobacter Pylori Prevalence and Associated Risk Factors in Individuals with Recurrent Epigastric Pain: Lahore, Pakistan
Keywords:Epigastric pain, Frequency, Gastritis, Helicobacter pylori, Risk factors
A number of stomach diseases, including gastritis, peptic ulcers, and gastric cancer, have been related to Helicobacter pylori (H. pylori), creating serious public health concerns. The current investigation aimed to determine the frequency of H. pylori infection and related risk factors in individuals having symptoms of recurring epigastric pain.
Methods: The present study involves 191 participants having recurring epigastric pain. Sociodemographic data, blood, and tissue samples were obtained from 112 patients between September 2020 to August 2021. Biochemical and molecular methods were used to estimate the infection frequency.
Results: The findings revealed that the overall infection ratio was 58% (n=65 out of 112). Males (n=41, 63.1%) contracted the infection more frequently than females. The participants belong to the 26-30 age group (n=37, 56.9%) low socioeconomic status (n=45, 69.2%), resided in rural areas (n=54, 83.1%), and consumed unfiltered water (n=57, 87.7%) had observed with significantly higher infection rates. The regression analysis demonstrated greater probability of contracting infection in male gender (OR 5.91, 95%CI: 2.40-12.9), in 26-35 age group (OR 6.16, 95%CI: 1.75-21.6), tap water users (OR 4.42, 95%CI: 1.72-11.3), rural area residents (OR 3.31, 95%CI:1.39-9.76), and low economic status group (OR 5.26, 95%CI:1.84-16.5) as p< 0.05).
Conclusion: The findings revealed the incidence of H. pylori infection (58%) and its associated risk factors in individuals having recurring epigastric pain. The results suggest that larger datasets are needed for future studies to accurately reflect infection frequency and risk factors to diagnose and treat the disease.
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