Screening of Risk Factors and Subclinical Aspects for Hepatitis A, B and C in the Hospitalized Drug Addictives in “Treatment And Rehabilitation Center” in District Kech, Balochistan
DOI:
https://doi.org/10.31580/pjmls.v6i2.2744Keywords:
Age groups, HAV, HBV, HCV, Hygiene condition, Injectable drug users, Prevalence, Risk factorsAbstract
Viral hepatitis is a serious health problem this study was aimed to investigate the prevalence of HAV, HBV and HCV in the injectable drug users (IDUs) admitted in Treatment and Rehabilitation Center for Drug Addicts in District Kech, with prior concentration given to the associated risk factors and sub-clinical aspects. During the study, a total of 436 IDUs blood simple were tested for the confirmation of HAV, HBV and HCV infections in Teaching Hospital Turbat. The socio-demographic data (e.g., age, gender, literacy, vaccination, economical and marital status), associated risk factors were also recorded in the questionnaire-based study. All the infected individuals were divided into three age groups i.e. group-I (10- 20 Yrs), group II (21-40Yrs) and group-III (41- 60 Yrs).Out of these 436 tested IDUs372 (85.32%) was found to have HAV, HBV and HCV infections. Out of 372 infected IDUs 13.30% (58/436) were infected with HAV, 30.73% (134/436) were infected with HBV and 41.28% (180/436) were infected with HCV. The prevalence of hepatitis infection was highest in group II 259/436 (59.40%), followed by group III 61/436 (13.90%), however least prevalence was found in group-I 52/436 (11.92%). The collected data showed that majority of hepatitis patients maintained the poor hygiene condition 246/436 (56.42%). A relatively lesser number of patients 126/436 (28.89%) were observed to have good hygiene condition. The most serious risk factors of HAV, HBV and HCV infections in IDUs of Treatment and Rehabilitation Center were notably the use of unsterilized syringe which is 75.92% and it’s shearing among themselves for injecting drugs, followed by hair dressing tools (30.50%), unsterilized surgical tools (25.46 %).
References
AA I, JC O. Diagnostic evaluation of hepatitis utilizing fuzzy clustering means. World. 2011;3(1):23-30.
Stark K, Bienzle U, Vonk R, Guggenmoos-Holzmann I. History of syringe sharing in prison and risk of hepatitis B virus, hepatitis C virus, and human immunodeficiency virus infection among injecting drug users in Berlin. International journal of epidemiology. 1997;26(6):1359-66.
Flores JE, Thompson AJ, Ryan M, Howell J. The global impact of hepatitis B vaccination on hepatocellular carcinoma. Vaccines. 2022;10(5):793.
Ndunda JM, Kimani H, Orinda G, Otieno S. Influence of socio-cultural factors on hepatitis B infection in Mombasa County, Kenya. International Journal of Community Medicine and Public Health. 2023;10(4):1322.
Franco E, Bagnato B, Marino MG, Meleleo C, Serino L, Zaratti L. Hepatitis B: Epidemiology and prevention in developing countries. World journal of hepatology. 2012;4(3):74.
Lavanchy D, Kane M. Global epidemiology of hepatitis B virus infection. Hepatitis B virus in human diseases. 2016:187-203.
de Martel C, Maucort‐Boulch D, Plummer M, Franceschi S. World‐wide relative contribution of hepatitis B and C viruses in hepatocellular carcinoma. Hepatology. 2015;62(4):1190-200.
Ismail M, Naseem M, Khan B, Baloch MC. Study on the Prevalence, Risk Factors and Clinical Aspects of Hepatitis A And B in Different Ethnic Groups of Quetta District. Pak-Euro Journal of Medical and Life Sciences. 2023;6(1):31-8.
Ali SA, Donahue RM, Qureshi H, Vermund SH. Hepatitis B and hepatitis C in Pakistan: prevalence and risk factors. International journal of infectious diseases. 2009;13(1):9-19.
Butt AS, Sharif F. Viral hepatitis in Pakistan: past, present, and future. Euroasian journal of hepato-gastroenterology. 2016;6(1):70.
Shayan SJ, Nazari R, Kiwanuka F. Prevalence of HIV and HCV among injecting drug users in three selected WHO-EMRO countries: a meta-analysis. Harm Reduction Journal. 2021;18(1):59.
Somi MH, Khayatzadeh S, Nalbandy M, Naghashi S, Nikniaz Z. Estimating the incidence rate of hepatitis B and C in East Azerbaijan, Islamic Republic of Iran. Eastern Mediterranean Health Journal. 2020;26(7):803-9.
Nelson PK, Mathers BM, Cowie B, Hagan H, Des Jarlais D, Horyniak D, et al. Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews. The Lancet. 2011;378(9791):571-83.
Kazi AM, Shah SA, Jenkins CA, Shepherd BE, Vermund SH. Risk factors and prevalence of tuberculosis, human immunodeficiency virus, syphilis, hepatitis B virus, and hepatitis C virus among prisoners in Pakistan. International Journal of Infectious Diseases. 2010;14:e60-e6.
Hahn JA, Page-Shafer K, Lum PJ, Bourgois P, Stein E, Evans JL, et al. Hepatitis C virus seroconversion among young injection drug users: relationships and risks. The Journal of infectious diseases. 2002;186(11):1558-64.
Idrees M, Lal A, Naseem M, Khalid M. High prevalence of hepatitis C virus infection in the largest province of Pakistan. Journal of digestive diseases. 2008;9(2):95-103.
Al Kanaani Z, Mahmud S, Kouyoumjian SP, Abu-Raddad LJ. The epidemiology of hepatitis C virus in Pakistan: systematic review and meta-analyses. Royal Society open science. 2018;5(4):180257.
Connolly D, Gilchrist G. Prevalence and correlates of substance use among transgender adults: A systematic review. Addictive behaviors. 2020;111:106544.
Farook Mİ, İlhan MN, Koçak C. Determination of epidemiological characteristics of addicts treated in drug addiction clinics in Kabul. Journal of ethnicity in substance abuse. 2022;21(3):1063-82.
Piaserico S, Messina F, Russo FP. Managing psoriasis in patients with HBV or HCV infection: practical considerations. American Journal of Clinical Dermatology. 2019;20:829-45.
Osasona OG, Adewale-Fashoro O, Olumade TJ, Oguzie J, George U, Ariyo OE, et al. Comparative serologic profiles of hepatitis B Virus (HBV) between HIV/HBV co-infected and Hbv mono-infected patients in Ile-Ife, Nigeria. Journal of Immunoassay and Immunochemistry. 2021;42(6):633-47.
Khalid GG, Kyaw KWY, Bousquet C, Auat R, Donchuk D, Trickey A, et al. From risk to care: the hepatitis C screening and diagnostic cascade in a primary health care clinic in Karachi, Pakistan—a cohort study. International Health. 2020;12(1):19-27.
Mansha S, Imran M, Shah AMUH, Jamal M, Ahmed F, Atif M, et al. Hepatitis B and C virus infections among human immunodeficiency virus-infected people who inject drugs in Lahore, Pakistan. Viral immunology. 2017;30(5):366-70.
Hennessey KA, Kim AA, Griffin V, Collins NT, Weinbaum CM, Sabin K. Prevalence of infection with hepatitis B and C viruses and co-infection with HIV in three jails: a case for viral hepatitis prevention in jails in the United States. Journal of Urban Health. 2009;86:93-105.
Maher L, Jalaludin B, Chant KG, Jayasuriya R, Sladden T, Kaldor JM, et al. Incidence and risk factors for hepatitis C seroconversion in injecting drug users in Australia. Addiction. 2006;101(10):1499-508.
Maher L, Li J, Jalaludin B, Chant KG, Kaldor JM. High hepatitis C incidence in new injecting drug users: a policy failure? Australian and New Zealand journal of public health. 2007;31(1):30-5.
Vittal A, Ghany MG. WHO guidelines for prevention, care and treatment of individuals infected with HBV: a US perspective. Clinics in Liver Disease. 2019;23(3):417-32.
Khan S, Shah S, Ashraf H. Predictive factors for acquiring HCV infection in the population residing in high endemic, resource-limited settings. Journal of Family Medicine and Primary Care. 2021;10(1):167.
Castaneda D, Gonzalez AJ, Alomari M, Tandon K, Zervos XB. From hepatitis A to E: A critical review of viral hepatitis. World journal of gastroenterology. 2021;27(16):1691.
Joukar F, Mansour-Ghanaei F, Soati F, Meskinkhoda P. Knowledge levels and attitudes of health care professionals toward patients with hepatitis C infection. World Journal of Gastroenterology: WJG. 2012;18(18):2238.
Kazmi SA, Rauf A, Alshahrani MM, Awadh AAA, Iqbal Z, Soltane R, et al. Hepatitis B among University Population: Prevalence, Associated Risk Factors, Knowledge Assessment, and Treatment Management. Viruses. 2022;14(9):1936.
Waheed U, Saba N, Wazeer A, Ahmed S. A systematic review and meta-analysis on the epidemiology of hepatitis B and hepatitis C virus among beta-thalassemia major patients in Pakistan. Journal of Laboratory Physicians. 2021;13(03):270-6.
Moraras K, Block J, Shiroma N, Cannizzo A, Cohen C. Protecting the rights of health care students living with hepatitis B under the Americans With Disabilities Act. Public Health Reports. 2020;135(1_suppl):13S-8S.
Doshani M, Weng M, Moore KL, Romero JR, Nelson NP. Recommendations of the Advisory Committee on Immunization Practices for use of hepatitis A vaccine for persons experiencing homelessness. Morbidity and Mortality Weekly Report. 2019;68(6):153.
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