Crimean-Congo Hemorrhagic Fever Status in Pakistan, Its Prevention and Control Measures
DOI:
https://doi.org/10.31580/pjmls.v7i2.2736Keywords:
Causing agent, CCHF, Diagnosis, Hemorrhage, Pakistan, Prevention, Transmission, TreatmentAbstract
The virus that causes Crimean Congo Hemorrhagic Fever is known as the Crimean Congo Hemorrhagic Fever Virus. This disease is zoonotic, meaning that it may be transmitted from animals to humans. The infection is passed on from person to person by the bite of an infected tick. However, the transmission of infection from one human to another is also conceivable by direct contact with the blood or other bodily fluids of an individual who is diagnosed with the disease. The disease known as Crimean-Congo Hemorrhagic Fever may be diagnosed using a variety of approaches, including the enzyme linked immune sorbent assay, immunofluorescence assay, and polymerase chain reaction. Since the first case in Pakistan was recorded in 1976, the nation has been hit by many epidemics throughout the country. Treatment for the infection often consists of supportive care and oral ribavirin administration. However, only the province of Balochistan is regarded to be an endemic area, despite the fact that many cases have been recorded from other regions in Pakistan. To date, Food and Drug Administration has not given its approval for the development of a vaccine that can treat or cure the disease. However, the disease can be prevented by using acaricides to kill ticks, raising awareness among people who are at high risk, and taking appropriate precautions when treating patients.References
Khurshid A, Hassan M, Alam MM, Aamir UB, Rehman L, Sharif S. CCHF virus variants in Pakistan and Afghanistan: Emerging diversity and epidemiology. J Clin Virol. 2015;67(April):25–30.
Mertens M, Schmidt K, Ozkul A, Groschup MH. The impact of Crimean-Congo hemorrhagic fever virus on public health. Antiviral Res. 2013;98(2):248–60.
Umair M, Khurshid A, Alam MM, Akhtar R, Salman M, Ikram A. Genetic diversity and phylogenetic analysis of crimean-congo hemorrhagic fever viruses circulating in Pakistan during 2019. PLoS Negl Trop Dis. 2020;14(6):1–11.
Lwande OW, Irura Z, Tigoi C, Chepkorir E, Orindi B, Musila L. Seroprevalence of Crimean Congo hemorrhagic fever virus in Ijara District, Kenya. Vector-Borne Zoonotic Dis. 2012;12(9):727–32.
Spengler JR, Bergeron É, Rollin PE. Seroepidemiological Studies of Crimean-Congo Hemorrhagic Fever Virus in Domestic and Wild Animals. PLoS Negl Trop Dis. 2016;10(1):1–28.
Khan A, Abbas G, Ullah N, Abbas SW. Crimean Congo hemorrhagic fever (CCHF) review. Adv Zool Bot. 2018;6(3):88-94.
Hussain B. Crimean-Congo Hemorrhagic Fever (CCHF): An Emerging Disease in Pakistan. Vet Sci Res Rev. 2016;2(1):11–22.
Shayan S, Bokaean M, Shahrivar MR, Chinikar S. Crimean-Congo hemorrhagic fever. Lab Med. 2015;46(3):180–9.
Chinikar S, Ghiasi SM, Hewson R, Moradi M, Haeri A. Crimean-Congo hemorrhagic fever in Iran and neighboring countries. J Clin Virol. 2010;47(2):110–4.
Farhadpour F, Telmadarraiy Z, Chinikar S, Akbarzadeh K, Moemenbellah-Fard MD, Faghihi F. Molecular detection of Crimean-Congo haemorrhagic fever virus in ticks collected from infested livestock populations in a New Endemic Area, South of Iran. Trop Med Int Heal. 2016;21(3):340–7.
Gargili A, Estrada-Peña A, Spengler JR, Lukashev A, Nuttall PA, Bente DA. The role of ticks in the maintenance and transmission of Crimean-Congo hemorrhagic fever virus: A review of published field and laboratory studies. Antiviral Res. 2017;144:93–119.
Aslam S, Latif MS, Daud M, Rahman ZU, Tabassum B, Riaz MS. Crimean-congo hemorrhagic fever: Risk factors and control measures for the infection abatement (Review). Biomed Reports. 2016;4(1):15–20.
Qidwai W. Crimean-Congo haemorrhagic fever: An emerging public health care challenge in Pakistan. J Coll Physicians Surg Pakistan. 2016;26(2):81–2.
Sheikh AS, Sheikh AA, Sheikh NS, Rafi-U-Shan, Asif M, Afridi F. Bi-annual surge of Crimean-Congo haemorrhagic fever (CCHF): A five-year experience. Int J Infect Dis. 2005;9(1):37–42.
Orindi B, Irura Z, Fischer A, Lwande OW, Sang R, Chepkorir E. Seroprevalence of Crimean Congo Hemorrhagic Fever Virus in Ijara District, Kenya. Vector-Borne Zoonotic Dis. 2012;12(9):727–32.
Vanhomwegen J, Alves MJ, Županc TA, Bino S, Chinikar S, Karlberg H. Diagnostic assays for Crimean-Congo hemorrhagic fever. Emerg Infect Dis. 2012;18(12):1958–65.
Emmerich P, Mika A, von Possel R, Rackow A, Liu Y, Schmitz H,. Sensitive and specific detection of Crimean-Congo Hemorrhagic Fever Virus (CCHFV)—Specific IgM and IgG antibodies in human sera using recombinant CCHFV nucleoprotein as antigen in μ-capture and IgG immune complex (IC) ELISA tests. PLoS Negl Trop Dis. 2018;12(3):1–24.
Wahid B, Altaf S, Naeem N, Ilyas N, Idrees M. Scoping review of Crimean-Congo hemorrhagic fever (CCHF) literature and implications of future research. J Coll Physicians Surg Pakistan. 2019;29(6):563–73.
Zohaib A, Saqib M, Athar MA, Hussain MH, Sial A, Tayyab MH, et al. Crimean-Congo Hemorrhagic. 2020;26(4):2015–7.
Emro WHO. WHO EMRO | Crimean-Congo haemorrhagic fever in Pakistan 25. 2014;(July):1–2.
Nieto NC, Khan K, Uhllah G, Teglas MB. The emergence and maintenance of vector-borne diseases in the khyber pakhtunkhwa province, and the federally administered tribal areas of Pakistan. Front Physiol. 2012;3 JUL:1–14.
Hasan Z, Atkinson B, Jamil B, Samreen A, Altaf L, Hewson R. Short report: Diagnostic testing for hemorrhagic fevers in Pakistan: 2007-2013. Am J Trop Med Hyg. 2014;91(6):1243–6.
Furqan M, Yaqub T, Ali M, Ul-rahman A, Bente DA. Acta Tropica Prevalence and phylogenetic analysis of Crimean-Congo hemorrhagic fever virus in ticks collected from Punjab province of Pakistan. Acta Trop. 2021;218(January):105892.
Alam MM, Khurshid A, Sharif S, Shaukat S, Rana MS, Angez M. Genetic analysis and epidemiology of Crimean Congo hemorrhagic fever viruses in Baluchistan province of Pakistan. BMC Infect Dis. 2013;13(1).
Gethmann M, Schulz A, Groschup MH, Conraths FJ. ur na l P of. 2019;
Altaf A, Luby S, Jamil A, Najam A, Aamir Z, Khan J, et al. Outbreak of Crimean-Congo haemorrhagic fever in Quetta, Pakistan: contact tracing and risk assessment. Trop Med Int Heal. 2003;3(11):878–82.
Shahid MF, Shabbir MZ, Ashraf K, Ali M, Yaqub S, Mukhtar N, et al. Seroprevalence of Crimean-Congo haemorrhagic fever among three selected risk human groups in disease-endemic region of Pakistan. Zoonoses Public Health. 2020;67(7):755–9.
Yousaf MZ, Ashfaq UA, Anjum KM, Fatima S. Crimean-Congo Hemorrhagic Fever (CCHF) in Pakistan: The “Bell” is Ringing Silently. 2018;28(2):93–100.
Kasi KK, Arnim F Von, Schulz A, Rehman A, Chudhary A, Oneeb M, et al. Crimean-Congo haemorrhagic fever virus in ticks collected from livestock in Balochistan , Pakistan. 2020;(January):1543–52.
Alam MM, Khurshid A, Rana MS, Aamir UB, Salman M, Ahmad M. Surveillance of Crimean-Congo haemorrhagic fever in Pakistan. Lancet Infect Dis. 2017;17(8):806.
Athar MN, Bashir K, Ahmad AM, Bashir N, Balouch AH, Khalid MA. Short Report: Crimean-Congo Hemorrhagic Fever Outbreak in Rawalpindi, Pakistan, February 2002. Am J Trop Med Hyg. 2018;69(3):284–7.
Rehman K, Asif M, Bettani K, Veletzky L, Afridi S, Ramharter M. Outbreak of Crimean-Congo haemorrhagic fever with atypical clinical presentation in the Karak District of Khyber Pakhtunkhwa , Pakistan. 2018;1–6.
Bartholomeusz A, Locarnini S. Associated With Antiviral Therapy. Antivir Ther. 2006;55(November 2005):52–5.
Saleem M, Shah SZ, Haidari A, Idrees F. Prevalence of Crimean-Congo hemorrhagic fever in Pakistan and its new research progress. J Coast Life Med. 2016;4(4):259–62.
Mofleh J, Ahmad AZ. Crimean–Congo haemorrhagic fever outbreak investigation in the Western Region of Afghanistan in 2008. East Mediterr Heal J. 2012;18(5):522–6.
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