Campylobacter Jejuni As an Emerging Multidrug-Resistant (MDR) Pathogen
DOI:
https://doi.org/10.31580/pjmls.v4iSpecial%20Is.2632Keywords:
Campylobacter jejuni, MDR Pathogen, Antibiotic resistanceAbstract
Antimicrobial resistance is a serious health problem? worldwide ,harming humans, environment and animals due to irrational and increase use of antibiotics in different areas (agriculture, farming, and human medicine).There are several factors contributing to the spread of drug resistance including the movement of diseased humans and animals, improper use of antibiotics, ineffective infection control measures, agricultural waste and environmental contaminants. Humans who are exposed to the pathogen Campylobacter get gastroenteritis, it is a gram negative bacteria needs microaerophilic environment for growth. Antibiotics such as fluoroquinolones and macrolides are the preferred medication for treating campylobacteriosis are losing their effectiveness against this food-borne zoonotic pathogen. As a zoonotic pathogen the infection spread to humans from animal reservior by contaminated food, water and milk. The use of antibiotics in agriculture, human medicine and in animals a as growth promoters can result in the emergence of Campylobacter resistance but the clinically significant antibiotics are losing their effectiveness against Campylobacter and the health of the general people is being harmed by this rising resistance. It is challenging to stop the the appearance and spread of Campylobacter that is resistant to antibiotics due to the zoonotic nature of the disease, which makes it susceptible to drugs utilised both in traditional remedy and livestock farming.The most common pathogen associated with human food-borne outbreaks is thought to be Campylobacter jejuni. Several studies conducted in the recent years have revealed antimicrobial resistance (AMR) in C. jejuni strains. Concerns are growing as a result of the WHO's current designation of C. jejuni as a "high priority pathogen" since it has become resistant to a number of medications, including fluoroquinolones, macrolides, and other groups which has limited the options for treatment.
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