Dietary Iron and Vitamin B12 Supplementation: Influence on Hematology and Biochemical Parameters in Guinea Pigs

Authors

  • Osman Ahmed Macow Department of Nutrition, Faculty of Veterinary Medicine and Animal Husbandry Horseed International University, Waaberi, Mogadishu, Somalia
  • Omer Zamzam Veterinary Clinic, Somali National University, Mogadishu, Banaadir, Somalia
  • Luna Apdi Karim Department of Nutrition, Faculty of Veterinary Medicine and Animal Husbandry Horseed International University, Waaberi, Mogadishu, Somalia
  • Ortho Mustafa Veterinary Clinic, Somali National University, Mogadishu, Banaadir, Somalia
  • Ayesha Abdirehman Department of Nutrition, Faculty of Veterinary Medicine and Animal Husbandry Horseed International University, Waaberi, Mogadishu, Somalia
  • Fufana O Mohamed Veterinary Clinic, Somali National University, Mogadishu, Banaadir, Somalia

Abstract

This study aimed to investigate the effects of dietary iron and vitamin B12 supplementation on hematological parameters and biochemical parameters in guinea pigs. The study found that the supplementation of iron and vitamin B12 improved the hematological and biochemical parameters in guinea pigs. Hematological parameters, including hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, were significantly higher in the iron, vitamin B12, and iron + vitamin B12 groups compared to the control group. Biochemical parameters, including serum total protein, albumin, globulin levels, and serum direct bilirubin levels, were also significantly improved in the iron and vitamin B12-supplemented groups. The study suggested that the combined supplementation of iron and vitamin B12 may have synergistic effects on hematological parameters. The study did not investigate the effects on body weight. Iron and vitamin B12 are essential micronutrients required for the proper functioning of various metabolic processes in the body. The results showed that the guinea pigs supplemented with iron and/or vitamin B12 had significantly higher levels of hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration compared to the control group. In addition, there were no significant differences in biochemical parameters such as total protein, albumin, total bilirubin, direct bilirubin, indirect bilirubin, alanine transaminase, aspartate transaminase, and alkaline phosphatase between the groups. These findings suggest that iron and vitamin B12 supplementation may improve hematological parameters in guinea pigs, but may not significantly affect their biochemical parameters. The present study's findings suggest that iron and vitamin B12 supplementation could be beneficial for individuals with iron and vitamin B12 deficiency. However, the study's limitations include a small sample size and being conducted on guinea pigs, so further research is needed to investigate the long-term effects of iron and vitamin B12 supplementation on hematological and biochemical parameters in humans.

Author Biographies

  • Osman Ahmed Macow, Department of Nutrition, Faculty of Veterinary Medicine and Animal Husbandry Horseed International University, Waaberi, Mogadishu, Somalia
    This study aimed to investigate the effects of dietary iron and vitamin B12 supplementation on hematological parameters and biochemical parameters in guinea pigs. The study found that the supplementation of iron and vitamin B12 improved the hematological and biochemical parameters in guinea pigs. Hematological parameters, including hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, were significantly higher in the iron, vitamin B12, and iron + vitamin B12 groups compared to the control group. Biochemical parameters, including serum total protein, albumin, globulin levels, and serum direct bilirubin levels, were also significantly improved in the iron and vitamin B12-supplemented groups. The study suggested that the combined supplementation of iron and vitamin B12 may have synergistic effects on hematological parameters. The study did not investigate the effects on body weight. Iron and vitamin B12 are essential micronutrients required for the proper functioning of various metabolic processes in the body. The results showed that the guinea pigs supplemented with iron and/or vitamin B12 had significantly higher levels of hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration compared to the control group. In addition, there were no significant differences in biochemical parameters such as total protein, albumin, total bilirubin, direct bilirubin, indirect bilirubin, alanine transaminase, aspartate transaminase, and alkaline phosphatase between the groups. These findings suggest that iron and vitamin B12 supplementation may improve hematological parameters in guinea pigs, but may not significantly affect their biochemical parameters. The present study's findings suggest that iron and vitamin B12 supplementation could be beneficial for individuals with iron and vitamin B12 deficiency. However, the study's limitations include a small sample size and being conducted on guinea pigs, so further research is needed to investigate the long-term effects of iron and vitamin B12 supplementation on hematological and biochemical parameters in humans.
  • Omer Zamzam, Veterinary Clinic, Somali National University, Mogadishu, Banaadir, Somalia
    This study aimed to investigate the effects of dietary iron and vitamin B12 supplementation on hematological parameters and biochemical parameters in guinea pigs. The study found that the supplementation of iron and vitamin B12 improved the hematological and biochemical parameters in guinea pigs. Hematological parameters, including hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, were significantly higher in the iron, vitamin B12, and iron + vitamin B12 groups compared to the control group. Biochemical parameters, including serum total protein, albumin, globulin levels, and serum direct bilirubin levels, were also significantly improved in the iron and vitamin B12-supplemented groups. The study suggested that the combined supplementation of iron and vitamin B12 may have synergistic effects on hematological parameters. The study did not investigate the effects on body weight. Iron and vitamin B12 are essential micronutrients required for the proper functioning of various metabolic processes in the body. The results showed that the guinea pigs supplemented with iron and/or vitamin B12 had significantly higher levels of hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration compared to the control group. In addition, there were no significant differences in biochemical parameters such as total protein, albumin, total bilirubin, direct bilirubin, indirect bilirubin, alanine transaminase, aspartate transaminase, and alkaline phosphatase between the groups. These findings suggest that iron and vitamin B12 supplementation may improve hematological parameters in guinea pigs, but may not significantly affect their biochemical parameters. The present study's findings suggest that iron and vitamin B12 supplementation could be beneficial for individuals with iron and vitamin B12 deficiency. However, the study's limitations include a small sample size and being conducted on guinea pigs, so further research is needed to investigate the long-term effects of iron and vitamin B12 supplementation on hematological and biochemical parameters in humans.
  • Luna Apdi Karim, Department of Nutrition, Faculty of Veterinary Medicine and Animal Husbandry Horseed International University, Waaberi, Mogadishu, Somalia
    This study aimed to investigate the effects of dietary iron and vitamin B12 supplementation on hematological parameters and biochemical parameters in guinea pigs. The study found that the supplementation of iron and vitamin B12 improved the hematological and biochemical parameters in guinea pigs. Hematological parameters, including hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, were significantly higher in the iron, vitamin B12, and iron + vitamin B12 groups compared to the control group. Biochemical parameters, including serum total protein, albumin, globulin levels, and serum direct bilirubin levels, were also significantly improved in the iron and vitamin B12-supplemented groups. The study suggested that the combined supplementation of iron and vitamin B12 may have synergistic effects on hematological parameters. The study did not investigate the effects on body weight. Iron and vitamin B12 are essential micronutrients required for the proper functioning of various metabolic processes in the body. The results showed that the guinea pigs supplemented with iron and/or vitamin B12 had significantly higher levels of hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration compared to the control group. In addition, there were no significant differences in biochemical parameters such as total protein, albumin, total bilirubin, direct bilirubin, indirect bilirubin, alanine transaminase, aspartate transaminase, and alkaline phosphatase between the groups. These findings suggest that iron and vitamin B12 supplementation may improve hematological parameters in guinea pigs, but may not significantly affect their biochemical parameters. The present study's findings suggest that iron and vitamin B12 supplementation could be beneficial for individuals with iron and vitamin B12 deficiency. However, the study's limitations include a small sample size and being conducted on guinea pigs, so further research is needed to investigate the long-term effects of iron and vitamin B12 supplementation on hematological and biochemical parameters in humans.
  • Ortho Mustafa, Veterinary Clinic, Somali National University, Mogadishu, Banaadir, Somalia
    This study aimed to investigate the effects of dietary iron and vitamin B12 supplementation on hematological parameters and biochemical parameters in guinea pigs. The study found that the supplementation of iron and vitamin B12 improved the hematological and biochemical parameters in guinea pigs. Hematological parameters, including hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, were significantly higher in the iron, vitamin B12, and iron + vitamin B12 groups compared to the control group. Biochemical parameters, including serum total protein, albumin, globulin levels, and serum direct bilirubin levels, were also significantly improved in the iron and vitamin B12-supplemented groups. The study suggested that the combined supplementation of iron and vitamin B12 may have synergistic effects on hematological parameters. The study did not investigate the effects on body weight. Iron and vitamin B12 are essential micronutrients required for the proper functioning of various metabolic processes in the body. The results showed that the guinea pigs supplemented with iron and/or vitamin B12 had significantly higher levels of hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration compared to the control group. In addition, there were no significant differences in biochemical parameters such as total protein, albumin, total bilirubin, direct bilirubin, indirect bilirubin, alanine transaminase, aspartate transaminase, and alkaline phosphatase between the groups. These findings suggest that iron and vitamin B12 supplementation may improve hematological parameters in guinea pigs, but may not significantly affect their biochemical parameters. The present study's findings suggest that iron and vitamin B12 supplementation could be beneficial for individuals with iron and vitamin B12 deficiency. However, the study's limitations include a small sample size and being conducted on guinea pigs, so further research is needed to investigate the long-term effects of iron and vitamin B12 supplementation on hematological and biochemical parameters in humans.
  • Ayesha Abdirehman, Department of Nutrition, Faculty of Veterinary Medicine and Animal Husbandry Horseed International University, Waaberi, Mogadishu, Somalia
    This study aimed to investigate the effects of dietary iron and vitamin B12 supplementation on hematological parameters and biochemical parameters in guinea pigs. The study found that the supplementation of iron and vitamin B12 improved the hematological and biochemical parameters in guinea pigs. Hematological parameters, including hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, were significantly higher in the iron, vitamin B12, and iron + vitamin B12 groups compared to the control group. Biochemical parameters, including serum total protein, albumin, globulin levels, and serum direct bilirubin levels, were also significantly improved in the iron and vitamin B12-supplemented groups. The study suggested that the combined supplementation of iron and vitamin B12 may have synergistic effects on hematological parameters. The study did not investigate the effects on body weight. Iron and vitamin B12 are essential micronutrients required for the proper functioning of various metabolic processes in the body. The results showed that the guinea pigs supplemented with iron and/or vitamin B12 had significantly higher levels of hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration compared to the control group. In addition, there were no significant differences in biochemical parameters such as total protein, albumin, total bilirubin, direct bilirubin, indirect bilirubin, alanine transaminase, aspartate transaminase, and alkaline phosphatase between the groups. These findings suggest that iron and vitamin B12 supplementation may improve hematological parameters in guinea pigs, but may not significantly affect their biochemical parameters. The present study's findings suggest that iron and vitamin B12 supplementation could be beneficial for individuals with iron and vitamin B12 deficiency. However, the study's limitations include a small sample size and being conducted on guinea pigs, so further research is needed to investigate the long-term effects of iron and vitamin B12 supplementation on hematological and biochemical parameters in humans.
  • Fufana O Mohamed, Veterinary Clinic, Somali National University, Mogadishu, Banaadir, Somalia
    This study aimed to investigate the effects of dietary iron and vitamin B12 supplementation on hematological parameters and biochemical parameters in guinea pigs. The study found that the supplementation of iron and vitamin B12 improved the hematological and biochemical parameters in guinea pigs. Hematological parameters, including hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration, were significantly higher in the iron, vitamin B12, and iron + vitamin B12 groups compared to the control group. Biochemical parameters, including serum total protein, albumin, globulin levels, and serum direct bilirubin levels, were also significantly improved in the iron and vitamin B12-supplemented groups. The study suggested that the combined supplementation of iron and vitamin B12 may have synergistic effects on hematological parameters. The study did not investigate the effects on body weight. Iron and vitamin B12 are essential micronutrients required for the proper functioning of various metabolic processes in the body. The results showed that the guinea pigs supplemented with iron and/or vitamin B12 had significantly higher levels of hemoglobin, red blood cells, packed cell volume, mean corpuscular volume, mean corpuscular hemoglobin, and mean corpuscular hemoglobin concentration compared to the control group. In addition, there were no significant differences in biochemical parameters such as total protein, albumin, total bilirubin, direct bilirubin, indirect bilirubin, alanine transaminase, aspartate transaminase, and alkaline phosphatase between the groups. These findings suggest that iron and vitamin B12 supplementation may improve hematological parameters in guinea pigs, but may not significantly affect their biochemical parameters. The present study's findings suggest that iron and vitamin B12 supplementation could be beneficial for individuals with iron and vitamin B12 deficiency. However, the study's limitations include a small sample size and being conducted on guinea pigs, so further research is needed to investigate the long-term effects of iron and vitamin B12 supplementation on hematological and biochemical parameters in humans.

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Published

2022-12-31

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Vol. 5 No. 4 (2022): October-December, 2022

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