Pattern and Prevalence of Congenital Malformation and Genetic Disorders among Offspring of Consanguineous Parents in Quetta

Authors

  • Ambreen Ijaz Deapartment of Zoology, , Sardar Bahadur Khan Women University, Quetta, Balochistan.
  • Maryam Muhammad Ali Department of Zoology, Sardar Bahadur Khan Women University (SBKWU), Quetta, Balochistan, Pakistan
  • Shubana Kausar Health Department, Helpers Eye Hospital, Quetta, Balochistan, Pakistan
  • Khadija Saif Gynaecology Unit 2, Sandamen Provincial Hospital, Quetta, Pakistan
  • Masooma Mukhtar Hussain Department of Zoology, Sardar Bahadur Khan Women University (SBKWU), Quetta, Balochistan, Pakistan
  • Razia Muhammad Tawakal Department of Zoology, Sardar Bahadur Khan Women University (SBKWU), Quetta, Balochistan, Pakistan
  • Palwasha Tariq Department of Physical Therapy, University of Arlington, Texas, USA
  • Tahir Hameed Center for Advanced Studies in Vaccinology and Biotechnology, University of Balochistan
  • Gul Makai Panezai Department of Zoology, Sardar Bahadur Khan Women University (SBKWU), Quetta, Balochistan, Pakistan
  • Muhammad Masood Tariq Kiani Center for Advanced Studies in Vaccinology and Biotechnology, University of Balochistan
  • Nosheen Rafique Department of Zoology, Sardar Bahadur Khan Women University (SBKWU), Quetta, Balochistan, Pakistan
  • Aasia Karim Department of Zoology, Sardar Bahadur Khan Women University (SBKWU), Quetta, Balochistan, Pakistan
  • Zuhra Bibi Department of Zoology, Sardar Bahadur Khan Women University (SBKWU), Quetta, Balochistan, Pakistan

DOI:

https://doi.org/10.31580/pjmls.v5i1.2470

Keywords:

Child mortality, Congenital anomalies, Consanguinity, Health problems

Abstract

This cross-sectional study was carried out to examine the pattern and prevalence of congenital malformation/ genetic disorders among the offspring of consanguineous marriages in Quetta, Pakistan. A survey was conducted among 105 married couples from different areas of Quetta city. 89 out of 105 consanguineous couples were related as first cousins, followed by second cousin (n=16) and third cousin (n=6) couples. Consanguineous marriages were common among women who were illiterate (43.8%) and unemployed (87.6%). Highest number of child mortality (61.9%) and abnormalities (32.1%) were observed among the children of first cousin marriages. The most common congenital malformation /genetic disorders were mental retardation (24.13%), followed by diabetes (10.3%), deafness (6.8%) and thalassemia (6.8%). Among all the inter-related marriages, first cousin marriages are at highest risk to have babies with congenital anomalies.

 

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Published

2022-04-05

Issue

Vol. 5 No. 1 (2022): March, 2022

Section