Effect of Musa Paradisiaca Leaves Ethanolic Extract on Memory and Learning Behavior in Mice Model
DOI:
https://doi.org/10.31580/pjmls.v4i3.2333Keywords:
Ethanolic extract, Mice model,, Learning, Memory, Musa paradisiaca leavesAbstract
Usually the learning and memory ability effected with ageing and stressful environment effect. Delay in onset duration and prevention of these diseases have a major influence on society by decreasing risk of disease and expenditures. There is no therapeutical treatment available which give cure from these diseases. Although number of drugs are present which better the memory and learning ability but has numerous side effect and dependence issue so it has been essential requirement to establish a well therapeutic substance for the learning and memory related issues. Herbals are rich source of phytochemicals which showed excellent protection against neurodegenerative disorders which give hope to establish antiamnesic drugs and treatment. Present study investigated the effect of Musa paradisiaca leaves ethanolic extract on exeroceptive and interoceptive test on learning and memory behavior by using mice model at different doses 50,100 and 200mg/kg. Exeroceptive test was evaluated by Elevated plus maze test while interoceptive test was evaluated by Scopolamine-induced amnesia. Result showed that MPL-EE at dose of 200mg/kg give significant reduction in transfer latency on both acquisition and retention days similar to standard drug which indicates that MPL-EE have excellent antiamnesic properties. Hence further investigation required to isolate constituent which use to discover new therapeutic agents.
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