Contribution of Common Single Nucleotide Polymorphisms in Noise-Induced Hearing Loss


NIHL, PON2, ATP2b2, CASP gene, CAT, cadherin 23, connexins, HSP haplotypes

How to Cite

WAHEED, F., & Shafique, M. A. (2020). Contribution of Common Single Nucleotide Polymorphisms in Noise-Induced Hearing Loss. Pak-Euro Journal of Medical and Life Sciences, 3(3), 121-130.


Noise induced hearing loss (NIHL), is common sensory illness especially occur in industrial areas, about 10% population affected annually. NIHL is second occupational and sensori-neural hearing disability all over the world. Since the description between PON2, ATP2B2, CASP gene, Potassium recycling genes (KCNE1, KCNJ10, KCNQ1, KCNMA1, KCNQ4), SLC12A2, SLC26A4, connexins (GJB2, GJB3, GJB6), myosin 14 genes, CAT SNPs/haplotypes, cadherin 23 & protocadherin 15 (CDH23, PCDH15), HSP haplotypes (HSP70-hom, HSP70-1 and HSP70-2) there have been significant advances in the understanding and genetic manipulation of this disease. This review focused on the genes involved in Noise induced hearing loss (NIHL). But all these genes are studied separately in different populations. One large research plan has to be introduced to identify common genes involved in this disease. We should have to know the mechanism of involvement of these genes in this disease.


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