Noise induced hearing loss (NIHL), is common sensory illness especially occur in industrial areas, about 10% population affected annually. NIHL is second occupational and sensori-neural hearing disability all over the world. Since the description between PON2, ATP2B2, CASP gene, Potassium recycling genes (KCNE1, KCNJ10, KCNQ1, KCNMA1, KCNQ4), SLC12A2, SLC26A4, connexins (GJB2, GJB3, GJB6), myosin 14 genes, CAT SNPs/haplotypes, cadherin 23 & protocadherin 15 (CDH23, PCDH15), HSP haplotypes (HSP70-hom, HSP70-1 and HSP70-2) there have been significant advances in the understanding and genetic manipulation of this disease. This review focused on the genes involved in Noise induced hearing loss (NIHL). But all these genes are studied separately in different populations. One large research plan has to be introduced to identify common genes involved in this disease. We should have to know the mechanism of involvement of these genes in this disease.
1. Sliwińiska-Kowalska M, Pawelczyk M, Kowalski TJ. Genetic factors in susceptibility to age-and noise-related hearing loss. Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego. 2006;21(124):384-8.
2. Yamasoba T, Lin FR, Someya S, Kashio A, Sakamoto T, Kondo K. Current concepts in age-related hearing loss: epidemiology and mechanistic pathways. Hearing research. 2013;303:30-8.
3. Fujimoto C, Yamasoba T. Oxidative stresses and mitochondrial dysfunction in age-related hearing loss. Oxidative medicine and cellular longevity. 2014;2014.
4. Kobel M, Le Prell CG, Liu J, Hawks JW, Bao J. Noise-induced cochlear synaptopathy: Past findings and future studies. Hearing research. 2017;349:148-54.
5. Yankaskas K, Hammill T, Packer M, Zuo J. Auditory injury-A military perspective. Hearing research. 2017;349:1.
6. Konings A, Van Laer L, Michel S, Pawelczyk M, Carlsson P-I, Bondeson M-L, et al. Variations in HSP70 genes associated with noise-induced hearing loss in two independent populations. European Journal of Human Genetics. 2009;17(3):329-35.
7. Heinrich U-R, Feltens R. Mechanisms underlying noise-induced hearing loss. Drug Discovery today: disease mechanisms. 2006;3(1):131-5.
8. Harding GW, Bohne BA, Vos JD. The effect of an age-related hearing loss gene (Ahl) on noise-induced hearing loss and cochlear damage from low-frequency noise. Hearing research. 2005;204(1-2):90-100.
9. Śliwińska-Kowalska M, Dudarewicz A, Kotyło P, Zamysłowska-Szmytke E, Pawlaczyk-Łuszczyńska M, Gajda-Szadkowska A. Individual susceptibility to noise-induced hearing loss: choosing an optimal method of retrospective classification of workers into noise-susceptible and noise-resistant groups. International journal of occupational medicine and environmental health. 2006;19(4):235-45.
10. Choi SH, Choi C-H. Noise-induced neural degeneration and therapeutic effect of antioxidant drugs. Journal of audiology & otology. 2015;19(3):111.
11. Yamashita D. Oxidative Stress in Noise-Induced Hearing Loss. Free Radicals in ENT Pathology: Springer; 2015. p. 147-61.
12. Dobie RA. The relative contributions of occupational noise and aging in individual cases of hearing loss. Ear and hearing. 1992;13(1):19-27.
13. Gong T-W, Lomax MI. Genes that influence susceptibility to noise-induced hearing loss. Noise-Induced Hearing Loss: Springer; 2012. p. 179-203.
14. Carlsson P-I, Van Laer L, Borg E, Bondeson M-L, Thys M, Fransen E, et al. The influence of genetic variation in oxidative stress genes on human noise susceptibility. Hearing Research. 2005;202(1-2):87-96.
15. Conway H, Simmons J, Talbert T. The purposes of occupational medical surveillance in US industry and related health findings. Journal of Occupational and Environmental Medicine. 1993;35(7):670-86.
16. Falasca V, Greco A, Ralli M. Noise induced hearing loss: the role of oxidative stress. Otolaryngol Open J. 2017;5:1-5.
17. Pawelczyk M, Van Laer L, Fransen E, Rajkowska E, Konings A, Carlsson PI, et al. Analysis of Gene Polymorphisms Associated with K+ Ion Circulation in the Inner Ear of Patients Susceptible and Resistant to Noise‐induced Hearing Loss. Annals of human genetics. 2009;73(4):411-21.
18. Lavinsky J, Ge M, Crow AL, Pan C, Wang J, Salehi P, et al. The genetic architecture of noise-induced hearing loss: Evidence for a gene-by-environment interaction. G3: Genes, Genomes, Genetics. 2016;6(10):3219-28.
19. Schwender H, Ruczinski I, Ickstadt K. Testing SNPs and sets of SNPs for importance in association studies. Biostatistics. 2011;12(1):18-32.
20. Le TN, Straatman LV, Lea J, Westerberg B. Current insights in noise-induced hearing loss: a literature review of the underlying mechanism, pathophysiology, asymmetry, and management options. Journal of Otolaryngology-Head & Neck Surgery. 2017;46(1):41.
21. Rabinowitz PM. The public health significance of noise-induced hearing loss. Noise-induced hearing loss: Springer; 2012. p. 13-25.
22. Win KN, Balalla NB, Lwin MZ, Lai A. Noise-induced hearing loss in the police force. Safety and health at work. 2015;6(2):134-8.
23. Musiba Z. The prevalence of noise-induced hearing loss among Tanzanian miners. Occupational Medicine. 2015;65(5):386-90.
24. Robinson T, Whittaker J, Acharya A, Singh D, Smith M. Prevalence of noise-induced hearing loss among woodworkers in Nepal: a pilot study. International journal of occupational and environmental health. 2015;21(1):14-22.
25. Sliwinska-Kowalska M, Pawelczyk M. Contribution of genetic factors to noise-induced hearing loss: a human studies review. Mutation Research/Reviews in Mutation Research. 2013;752(1):61-5.
26. Smoorenburg GF. Speech reception in quiet and in noisy conditions by individuals with noise‐induced hearing loss in relation to their tone audiogram. The journal of the acoustical society of America. 1992;91(1):421-37.
27. Liu Y-M, Li X-D, Guo X, Liu B, Lin A-H, Rao S-Q. Association between polymorphisms in SOD1 and noise-induced hearing loss in Chinese workers. Acta oto-laryngologica. 2010;130(4):477-86.
28. Li X, Cao J, Wang J, Song H, Ji G, Dong Q, et al. PON2 and ATP2B2 gene polymorphisms with noise-induced hearing loss. Journal of thoracic disease. 2016;8(3):430.
29. Basner M, Babisch W, Davis A, Brink M, Clark C, Janssen S, et al. Auditory and non-auditory effects of noise on health. The lancet. 2014;383(9925):1325-32.
30. Grondin Y, Bortoni ME, Sepulveda R, Ghelfi E, Bartos A, Cotanche D, et al. Genetic polymorphisms associated with hearing threshold shift in subjects during first encounter with occupational impulse noise. PLoS One. 2015;10(6):e0130827.
31. Committee HC. ACOEM evidence-based statement: noise-induced hearing loss. Journal of occupational and environmental medicine. 2003;45(6):579.
32. Baig A. Biological Properties, Clinical Implications and Role as Oxidative Biomarker of Human Paraoxonase: University of Karachi, Karachi.; 2018.
33. Zhang S, Ding E, Yin H, Zhang H, Zhu B. Research and Discussion on the Relationships between Noise-Induced Hearing Loss and ATP2B2 Gene Polymorphism. International Journal of Genomics. 2019;2019.
34. Wu Y, Ni J, Qi M, Cao C, Shao Y, Xu L, et al. Associations of genetic variation in CASP3 gene with noise-induced hearing loss in a Chinese population: a case–control study. Environmental Health. 2017;16(1):78.
35. Wangemann P. Supporting sensory transduction: cochlear fluid homeostasis and the endocochlear potential. The Journal of physiology. 2006;576(1):11-21.
36. Niu X, Canlon B. Protective mechanisms of sound conditioning. Advances in Otorhinolaryngology. 2002;59:96-105.
37. Konings A, Van Laer L, Pawelczyk M, Carlsson P-I, Bondeson M-L, Rajkowska E, et al. Association between variations in CAT and noise-induced hearing loss in two independent noise-exposed populations. Human molecular genetics. 2007;16(15):1872-83.
38. Müller U. Cadherins and mechanotransduction by hair cells. Current opinion in cell biology. 2008;20(5):557-66.
39. Sakaguchi H, Tokita J, Müller U, Kachar B. Tip links in hair cells: molecular composition and role in hearing loss. Current opinion in otolaryngology & head and neck surgery. 2009;17(5):388.
40. Bork JM, Peters LM, Riazuddin S, Bernstein SL, Ahmed ZM, Ness SL, et al. Usher syndrome 1D and nonsyndromic autosomal recessive deafness DFNB12 are caused by allelic mutations of the novel cadherin-like gene CDH23. The American Journal of Human Genetics. 2001;68(1):26-37.
41. Ahmed ZM, Riazuddin S, Ahmad J, Bernstein SL, Guo Y, Sabar MF, et al. PCDH15 is expressed in the neurosensory epithelium of the eye and ear and mutant alleles are responsible for both USH1F and DFNB23. Human molecular genetics. 2003;12(24):3215-23.
42. Yang M, Tan H, Zheng J, Wang F, Jiang C, He M, et al. Association of cadherin CDH23 gene polymorphisms with noise induced hearing loss in Chinese workers. Wei Sheng yan jiu= Journal of Hygiene Research. 2006;35(1):19-22.
43. Sliwinska‐Kowalska M, Noben‐Trauth K, Pawelczyk M, Kowalski TJ. Single nucleotide polymorphisms in the cadherin 23 (CDH23) gene in Polish workers exposed to industrial noise. American Journal of Human Biology. 2008;20(4):481-3.
44. Kikuchi T, Adams JC, Miyabe Y, So E, Kobayashi T. Potassium ion recycling pathway via gap junction systems in the mammalian cochlea and its interruption in hereditary nonsyndromic deafness. Medical electron microscopy. 2000;33(2):51-6.
45. Zhao H-B, Kikuchi T, Ngezahayo A, White T. Gap junctions and cochlear homeostasis. The Journal of membrane biology. 2006;209(2-3):177.
46. Gabriel H, Kupsch P, Sudendey J, Winterhager E, Jahnke K, Lautermann J. Mutations in the connexin26/GJB2 gene are the most common event in non‐syndromic hearing loss among the German population. Human mutation. 2001;17(6):521-2.
47. Van Eyken E, Van Laer L, Fransen E, Topsakal V, Hendrickx J-J, Demeester K, et al. The contribution of GJB2 (Connexin 26) 35delG to age-related hearing impairment and noise-induced hearing loss. Otology & Neurotology. 2007;28(7):970-5.
48. Konings A, Van Laer L, Wiktorek‐Smagur A, Rajkowska E, Pawelczyk M, Carlsson P, et al. Candidate Gene Association Study for Noise‐induced Hearing Loss in Two Independent Noise‐exposed Populations. Annals of human genetics. 2009;73(2):215-24.
49. Donaudy F, Snoeckx R, Pfister M, Zenner H-P, Blin N, Di Stazio M, et al. Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4). The American Journal of Human Genetics. 2004;74(4):770-6.
50. Mohammadi S, Mazhari MM, Mehrparvar AH, Attarchi MS. Cigarette smoking and occupational noise-induced hearing loss. European journal of public health. 2010;20(4):452-5.
51. Konings A, Van Laer L, Van Camp G. Genetic studies on noise-induced hearing loss: a review. Ear and hearing. 2009;30(2):151-9.
52. Fortunato G, Marciano E, Zarrilli F, Mazzaccara C, Intrieri M, Calcagno G, et al. Paraoxonase and superoxide dismutase gene polymorphisms and noise-induced hearing loss. Clinical chemistry. 2004;50(11):2012-8.
53. Li X-T, Li X, Hu F-F, Shen H-X, Cao J-L, Zhong L, et al. Association between paraoxonase 2 gene polymorphisms and noise-induced hearing loss in the chinese population. Journal of occupational health. 2013:12-0242-OA.
54. Wu S, Yu J, Jiao J, Chen G, Zhang C, Yu S. Association between PON2 gene polymorphisms and susceptibility to noise-induced hearing loss. Zhonghua lao Dong wei Sheng zhi ye Bing za zhi= Zhonghua Laodong Weisheng Zhiyebing Zazhi= Chinese Journal of Industrial Hygiene and Occupational Diseases. 2020;38(2):128-32.
55. Bhatt IS, Dias R, Washnik N, Wang J, Guthrie On, Skelton M, et al. Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians. Otology & neurotology: official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology. 2020;41(5):e538.
56. Sherman L, Dafni N, Lieman-Hurwitz J, Groner Y. Nucleotide sequence and expression of human chromosome 21-encoded superoxide dismutase mRNA. Proceedings of the National Academy of Sciences. 1983;80(18):5465-9.
57. Jamesdaniel S, Rosati R, Westrick J, Ruden DM. Chronic lead exposure induces cochlear oxidative stress and potentiates noise-induced hearing loss. Toxicology letters. 2018;292:175-80.
58. Harrison GS, Drabkin HA, Kao F-T, Hartz J, Hart IM, Chu EH, et al. Chromosomal location of human genes encoding major heat-shock protein HSP70. Somatic cell and molecular genetics. 1987;13(2):119-30.
59. Grillet N, Schwander M, Hildebrand MS, Sczaniecka A, Kolatkar A, Velasco J, et al. Mutations in LOXHD1, an evolutionarily conserved stereociliary protein, disrupt hair cell function in mice and cause progressive hearing loss in humans. The American Journal of Human Genetics. 2009;85(3):328-37.
60. Morita Y, Hirokawa S, Kikkawa Y, Nomura T, Yonekawa H, Shiroishi T, et al. Fine mapping of Ahl3 affecting both age-related and noise-induced hearing loss. Biochemical and biophysical research communications. 2007;355(1):117-21.
61. Davis R, Kozel P, Erway L. Genetic influences in individual susceptibility to noise: a review. Noise and Health. 2003;5(20):19.
62. Di Palma F, Holme RH, Bryda EC, Belyantseva IA, Pellegrino R, Kachar B, et al. Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D. Nature genetics. 2001;27(1):103-7.
63. Themann C, Suter AH, Stephenson MR, editors. National research agenda for the prevention of occupational hearing loss—Part 1. Seminars in Hearing; 2013: Thieme Medical Publishers.
64. Chien W, Lin FR. Prevalence of hearing aid use among older adults in the United States. Archives of internal medicine. 2012;172(3):292-3.