Pathogenicity of Clostridium Perfringens: A Short Review

Authors

  • Aroosa Akram Center for Advanced Studies in Vaccinology and Biotechnology, (CASVAB), UoB, Quetta
  • Imran Taj Hassani Center for Advanced Studies in Vaccinology and Biotechnology
  • Muhammad Ali Khan Center for Advanced Studies in Vaccinology and Biotechnology, (CASVAB), UoB, Quetta
  • Muhammad Kamran Taj Center for Advanced Studies in Vaccinology and Biotechnology, (CASVAB), UoB, Quetta
  • Muhammad Tariq Hasni Department of Orthopedics, Bolan Medical Collage, Quetta, Pakistan
  • Masroora Ali Khan Department of Microbiology, Sardar Bahadur Khan Women's University, Quetta, Pakistan
  • Bilal Javed Center for Advanced Studies in Vaccinology and Biotechnology, (CASVAB), UoB, Quetta

DOI:

https://doi.org/10.31580/pjmls.v4iSpecial%20Is.1113

Keywords:

Antibiotic resistance, Clostridium perfringens, Foodborne infections, Gastroenteritis, Necrotic enteritis, One Health, Prevalence, Toxins

Abstract

Clostridium perfringens has been linked to a number of illnesses in both people and animals. It causes various diseases, including gas gangrene, foodborne infections, antibiotic-associated diarrhea, and necrotic enteritis, by producing a variety of toxins. The bacterium, widespread in the environment, can contaminate food and cause food poisoning epidemics. The virulence factors and toxin classes revealed by C. perfringens are numerous, including alpha, beta, epsilon, iota, enterotoxin, and NetB. Growing concerns about antibiotic resistance in C. perfringens underline the necessity of careful antibiotic use. Distinct antibiotic resistance patterns have been found in many regions where C. perfringens is prevalent, including Pakistan, Iran, China, and India. Because of the contaminated water and vectors that result from floods, there is an increased risk of disease outbreaks, especially gastroenteritis. The health concerns connected with flooding must be reduced through proper sanitation, clean water access and hygiene practices. Recognizing the interdependence of humans, animals and nature in the spread of diseases, the "One Health" concept is crucial in nations like Pakistan. It is crucial to implement strict sanitation procedures and quality control techniques to ensure the safety of the meat. For efficient preventative and therapeutic methods, it is crucial to comprehend the prevalence, spread, factors affecting virulence, and antibiotic resistance of C. perfringens.

Author Biographies

  • Imran Taj Hassani, Center for Advanced Studies in Vaccinology and Biotechnology
    Clostridium perfringens has been linked to a number of illnesses in both people and animals. It causes various diseases, including gas gangrene, foodborne infections, antibiotic-associated diarrhea, and necrotic enteritis, by producing a variety of toxins. The bacterium, widespread in the environment, can contaminate food and cause food poisoning epidemics. The virulence factors and toxin classes revealed by C. perfringens are numerous, including alpha, beta, epsilon, iota, enterotoxin, and NetB. Growing concerns about antibiotic resistance in C. perfringens underline the necessity of careful antibiotic use. Distinct antibiotic resistance patterns have been found in many regions where C. perfringens is prevalent, including Pakistan, Iran, China, and India. Because of the contaminated water and vectors that result from floods, there is an increased risk of disease outbreaks, especially gastroenteritis. The health concerns connected with flooding must be reduced through proper sanitation, clean water access and hygiene practices. Recognizing the interdependence of humans, animals and nature in the spread of diseases, the "One Health" concept is crucial in nations like Pakistan. It is crucial to implement strict sanitation procedures and quality control techniques to ensure the safety of the meat. For efficient preventative and therapeutic methods, it is crucial to comprehend the prevalence, spread, factors affecting virulence, and antibiotic resistance of C. perfringens.
  • Muhammad Ali Khan, Center for Advanced Studies in Vaccinology and Biotechnology, (CASVAB), UoB, Quetta
    Clostridium perfringens has been linked to a number of illnesses in both people and animals. It causes various diseases, including gas gangrene, foodborne infections, antibiotic-associated diarrhea, and necrotic enteritis, by producing a variety of toxins. The bacterium, widespread in the environment, can contaminate food and cause food poisoning epidemics. The virulence factors and toxin classes revealed by C. perfringens are numerous, including alpha, beta, epsilon, iota, enterotoxin, and NetB. Growing concerns about antibiotic resistance in C. perfringens underline the necessity of careful antibiotic use. Distinct antibiotic resistance patterns have been found in many regions where C. perfringens is prevalent, including Pakistan, Iran, China, and India. Because of the contaminated water and vectors that result from floods, there is an increased risk of disease outbreaks, especially gastroenteritis. The health concerns connected with flooding must be reduced through proper sanitation, clean water access and hygiene practices. Recognizing the interdependence of humans, animals and nature in the spread of diseases, the "One Health" concept is crucial in nations like Pakistan. It is crucial to implement strict sanitation procedures and quality control techniques to ensure the safety of the meat. For efficient preventative and therapeutic methods, it is crucial to comprehend the prevalence, spread, factors affecting virulence, and antibiotic resistance of C. perfringens.
  • Muhammad Kamran Taj, Center for Advanced Studies in Vaccinology and Biotechnology, (CASVAB), UoB, Quetta
    Clostridium perfringens has been linked to a number of illnesses in both people and animals. It causes various diseases, including gas gangrene, foodborne infections, antibiotic-associated diarrhea, and necrotic enteritis, by producing a variety of toxins. The bacterium, widespread in the environment, can contaminate food and cause food poisoning epidemics. The virulence factors and toxin classes revealed by C. perfringens are numerous, including alpha, beta, epsilon, iota, enterotoxin, and NetB. Growing concerns about antibiotic resistance in C. perfringens underline the necessity of careful antibiotic use. Distinct antibiotic resistance patterns have been found in many regions where C. perfringens is prevalent, including Pakistan, Iran, China, and India. Because of the contaminated water and vectors that result from floods, there is an increased risk of disease outbreaks, especially gastroenteritis. The health concerns connected with flooding must be reduced through proper sanitation, clean water access and hygiene practices. Recognizing the interdependence of humans, animals and nature in the spread of diseases, the "One Health" concept is crucial in nations like Pakistan. It is crucial to implement strict sanitation procedures and quality control techniques to ensure the safety of the meat. For efficient preventative and therapeutic methods, it is crucial to comprehend the prevalence, spread, factors affecting virulence, and antibiotic resistance of C. perfringens.
  • Muhammad Tariq Hasni, Department of Orthopedics, Bolan Medical Collage, Quetta, Pakistan
    Clostridium perfringens has been linked to a number of illnesses in both people and animals. It causes various diseases, including gas gangrene, foodborne infections, antibiotic-associated diarrhea, and necrotic enteritis, by producing a variety of toxins. The bacterium, widespread in the environment, can contaminate food and cause food poisoning epidemics. The virulence factors and toxin classes revealed by C. perfringens are numerous, including alpha, beta, epsilon, iota, enterotoxin, and NetB. Growing concerns about antibiotic resistance in C. perfringens underline the necessity of careful antibiotic use. Distinct antibiotic resistance patterns have been found in many regions where C. perfringens is prevalent, including Pakistan, Iran, China, and India. Because of the contaminated water and vectors that result from floods, there is an increased risk of disease outbreaks, especially gastroenteritis. The health concerns connected with flooding must be reduced through proper sanitation, clean water access and hygiene practices. Recognizing the interdependence of humans, animals and nature in the spread of diseases, the "One Health" concept is crucial in nations like Pakistan. It is crucial to implement strict sanitation procedures and quality control techniques to ensure the safety of the meat. For efficient preventative and therapeutic methods, it is crucial to comprehend the prevalence, spread, factors affecting virulence, and antibiotic resistance of C. perfringens.
  • Masroora Ali Khan, Department of Microbiology, Sardar Bahadur Khan Women's University, Quetta, Pakistan
    Clostridium perfringens has been linked to a number of illnesses in both people and animals. It causes various diseases, including gas gangrene, foodborne infections, antibiotic-associated diarrhea, and necrotic enteritis, by producing a variety of toxins. The bacterium, widespread in the environment, can contaminate food and cause food poisoning epidemics. The virulence factors and toxin classes revealed by C. perfringens are numerous, including alpha, beta, epsilon, iota, enterotoxin, and NetB. Growing concerns about antibiotic resistance in C. perfringens underline the necessity of careful antibiotic use. Distinct antibiotic resistance patterns have been found in many regions where C. perfringens is prevalent, including Pakistan, Iran, China, and India. Because of the contaminated water and vectors that result from floods, there is an increased risk of disease outbreaks, especially gastroenteritis. The health concerns connected with flooding must be reduced through proper sanitation, clean water access and hygiene practices. Recognizing the interdependence of humans, animals and nature in the spread of diseases, the "One Health" concept is crucial in nations like Pakistan. It is crucial to implement strict sanitation procedures and quality control techniques to ensure the safety of the meat. For efficient preventative and therapeutic methods, it is crucial to comprehend the prevalence, spread, factors affecting virulence, and antibiotic resistance of C. perfringens.
  • Bilal Javed, Center for Advanced Studies in Vaccinology and Biotechnology, (CASVAB), UoB, Quetta
    Clostridium perfringens has been linked to a number of illnesses in both people and animals. It causes various diseases, including gas gangrene, foodborne infections, antibiotic-associated diarrhea, and necrotic enteritis, by producing a variety of toxins. The bacterium, widespread in the environment, can contaminate food and cause food poisoning epidemics. The virulence factors and toxin classes revealed by C. perfringens are numerous, including alpha, beta, epsilon, iota, enterotoxin, and NetB. Growing concerns about antibiotic resistance in C. perfringens underline the necessity of careful antibiotic use. Distinct antibiotic resistance patterns have been found in many regions where C. perfringens is prevalent, including Pakistan, Iran, China, and India. Because of the contaminated water and vectors that result from floods, there is an increased risk of disease outbreaks, especially gastroenteritis. The health concerns connected with flooding must be reduced through proper sanitation, clean water access and hygiene practices. Recognizing the interdependence of humans, animals and nature in the spread of diseases, the "One Health" concept is crucial in nations like Pakistan. It is crucial to implement strict sanitation procedures and quality control techniques to ensure the safety of the meat. For efficient preventative and therapeutic methods, it is crucial to comprehend the prevalence, spread, factors affecting virulence, and antibiotic resistance of C. perfringens.

References

Uzal FA, Freedman JC, Shrestha A, Theoret JR, Garcia J, Awad MM, Adams V, Moore RJ, Rood JI, McClane BA. Towards an understanding of the role of Clostridium perfringens toxins in human and animal disease. Future microbiology. 2014;9(3):361-77.

Revitt-Mills SA, Rood JI, Adams V. Clostridium perfringens extracellular toxins and enzymes: 20 and counting. Microbiology Australia. 2015;36(3):114-7.

Rood JI, Adams V, Lacey J, Lyras D, McClane BA, Melville SB, Moore RJ, Popoff MR, Sarker MR, Songer JG, Uzal FA. Expansion of the Clostridium perfringens toxin-based typing scheme. Anaerobe. 2018;53:5-10.

Cooper KK, Songer JG. Necrotic enteritis in chickens: a paradigm of enteric infection by Clostridium perfringens type A. Anaerobe. 2009 Feb 1;15(1-2):55-60.

Stevens DL, Aldape MJ, Bryant AE. Life-threatening clostridial infections. Anaerobe. 2012;18(2):254-9.

Uzal FA, McClane BA. Recent progress in understanding the pathogenesis of Clostridium perfringens type C infections. Veterinary microbiology. 2011;153(1-2):37-43.

Silva FV. High pressure thermal processing for the inactivation of Clostridium perfringens spores in beef slurry. Innovative Food Science & Emerging Technologies. 2016;33:26-31.

Navarro MA, McClane BA, Uzal FA. Mechanisms of action and cell death associated with Clostridium perfringens toxins. Toxins. 2018;10(5):212.

Goossens E, Verherstraeten S, Valgaeren BR, Pardon B, Timbermont L, Schauvliege S, Rodrigo-Mocholí D, Haesebrouck F, Ducatelle R, Deprez PR, Van Immerseel F. The C-terminal domain of Clostridium perfringens alpha toxin as a vaccine candidate against bovine necrohemorrhagic enteritis. Veterinary research. 2016;47:1-9.

Ko EK, Moon JS, Wee SH, Bahk GJ. Quantitative microbial risk assessment of Clostridium perfringens on ham and sausage products in Korea. Food Science of Animal Resources. 2012;32(1):118-24.

Heredia NL, Labbé RG. Clostridium perfringens. Guide to foodborne pathogens. 2001:133-42.

McClane BA, Robertson SL, Li J. Clostridium perfringens. Food microbiology: fundamentals and frontiers. 2012:465-89.

Smedley III JG, McClane BA. Fine mapping of the N-terminal cytotoxicity region of Clostridium perfringens enterotoxin by site-directed mutagenesis. Infection and Immunity. 2004;72(12):6914-23.

Lindström M, Heikinheimo A, Lahti P, Korkeala H. Novel insights into the epidemiology of Clostridium perfringens type A food poisoning. Food microbiology. 2011;28(2):192-8.

Ullah S, Taj I. Isolation and PCR Based Identification of Clostridium Perfringens in Beef Samples from Quetta City. Pak-Euro Journal of Medical and Life Sciences. 2021;4(3):201-6.

Yelland TS, Naylor CE, Bagoban T, Savva CG, Moss DS, McClane BA, Blasig IE, Popoff M, Basak AK. Structure of a C. perfringens enterotoxin mutant in complex with a modified Claudin-2 extracellular loop 2. Journal of Molecular Biology. 2014;426(18):3134-47.

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Published

2023-07-16

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Vol. 4 No. Special Is (2021): Review Articles May, 2021- December, 2023

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